Recruiting

Observational Study

Sponsor:

Thomas Jefferson University

Code:

NCT06272123

Conditions

Chronic Sinusitis

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

no intervention

Study Details

Brief summary:

A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients

Conditions

Chronic Sinusitis

Study ID

NCT06272123

Start date

Jan 1, 2024

Status verified date

Feb, 2024

Completion date

Jan 31, 2026

Anticipated

Primary completion date

Jan 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients with Chronic sinusitis (with or without polyps)
  • Undergoing endoscopic sinus surgery during the study period
  • More than 18 years
  • No chronic illness/ malignancy

Study Design

Enrollment

200 participants

Anticipated

Interventions and Outcome Measures

Arms

Chronic Sinusitis

Controls

Interventions

no intervention

no intervention

Primary outcome measure

  • Endotypic markers [ Time Frame: 1 year ]

Central Contacts and Locations

Locations

Thomas Jefferson University Department of Otolaryngology

Recruiting

Philadelphia, Pennsylvania, United States, 19107

Contacts

Elizabeth Kangas, RN, BSN

215-955-6784elizabeth.kangas@jefferson.edu

More Information

Sponsor

Thomas Jefferson University

Last update posted

Feb 22, 2024

Last verified

Feb, 2024

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Thomas Jefferson University on 2024-02-22.