Recruiting

Observational Study

Sponsor:

University of Pittsburgh

Code:

NCT06275308

Conditions

Intraocular Pressure

Eligibility Criteria

Sex: All

Age: 0 - 8

Healthy Volunteers: Accepted

Interventions

Ventilation manipulation

Study Details

Brief summary:

This study is to investigate the relationship between arterial carbon dioxide (CO2) concentration and vitreous pressure on the choroidal volume by integrated intraoperative OCT imaging under eye exams under anesthesia.

Conditions

Intraocular Pressure

Study ID

NCT06275308

Start date

Feb 27, 2023

Status verified date

Jan, 2026

Completion date

Dec 30, 2026

Anticipated

Primary completion date

Dec 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 8

Healthy Volunteers: Accepted

Inclusion Criteria:

  • any child undergoing an eye exam under anesthesia for an ophthalmologic reason.
  • children between the ages newborn to 8 years of age.

Exclusion Criteria:

  • children who are not having an eye exam under anesthesia.
  • children with a known medical diagnosis that affect the eye to be studied
  • \* children over the age of 8 years of age.
  • \* children with altered cerebral autoregulation, increased intracranial pressure, pulmonary hypertension, or any other condition deemed appropriate by the anesthesiologist.
  • children in whom a laryngeal mask airway will not be used

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Observational Group

Manipulation of end tidal carbon dioxide in subjects

Interventions

Ventilation manipulation

Effects of ventilation manipulation to achieve desired levels of end tidal carbon dioxide

Primary outcome measure

  • Intraocular Pressure (IOP) (mmHg) [ Time Frame: After induction of anesthesia end tidal CO2 will be manipulated to 40mmHg, then 30mmHg and then 50mmHg. The end tidal CO2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period IOP measured ]

Central Contacts and Locations

Central contacts

Amy Monroe, MPH, MBA

412-623-6382monroeal@upmc.edu

Alisha Maslanka, BS, CCRC

412-491-2748alisha.maslanka@chp.edu

Locations

University of Pittsburgh Medical Center

Recruiting

Pittsburgh, Pennsylvania, United States, 15224

Contacts

Amy Monroe, MPH, MBA

monroeal@upmc.edu

Principal Investigator:

Kanwal Nischal, MD,FRCOphth

More Information

Sponsor

University of Pittsburgh

Last update posted

Jan 9, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Pittsburgh on 2026-01-09.