Recruiting

Nasal Antisepsis

Sponsor:

Mary K Hayden

Code:

NCT06282510

Conditions

Candida Auris Infection

Colonization, Asymptomatic

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Povidone Iodine Topical

Study Details

Brief summary:

This is a randomized, controlled, open-label trial of effect of 10% povidone iodine intranasal antisepsis on the detection of Candida auris.

Conditions

Candida Auris Infection

Colonization, Asymptomatic

Study ID

NCT06282510

Start date

Jan 29, 2024

Status verified date

Oct, 2025

Completion date

Dec, 2028

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • History of C. auris colonization or infection
  • Patient in a participating facility

Exclusion Criteria:

  • History of severe allergy to iodine-based products, defined as anaphylaxis or rash
  • Currently breastfeeding or pregnant
  • Non-English language speaking

Study Design

Enrollment

120 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

active comparator: Intranasal Povidone Iodine

Nasal iodophor applied twice daily for five days.

no intervention: Control

Routine care.

Interventions

Povidone Iodine Topical

Topical intranasal povidone iodine (10%) twice daily for 5 days

Primary outcome measure

  • Detection of C. auris from the anterior nares [ Time Frame: Through study completion and data analysis in three years (2028) ]

Central Contacts and Locations

Central contacts

Sarah E. Sansom, DO

3125636201sarah_e_sansom@rush.edu

Mary K. Hayden, MD

3129428727mhayden@rush.edu

Locations

Rush University Medical Center

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Sarah E Sansom, DO

312-563-6201sarah_e_sansom@rush.edu

Mary K Hayden, MD

312-942-8727mhayden@rush.edu

RML Specialty Hospital

Recruiting

Chicago, Illinois, United States, 60624

Contacts

Nidhi Undevia, MD

630-286-4000nundevia@rmlspecialtyhospital.org

Lisa Duffner

630-286-4000LMikolajewski@rmlspecialtyhospital.org

RML Specialty Hospital

Recruiting

Hinsdale, Illinois, United States, 60521

Contacts

Nidhi Undevia, MD

630-286-4000nundevia@rmlspecialtyhospital.org

Lisa Duffner

(630) 286-4000LMikolajewski@rmlspecialtyhospital.org

More Information

Sponsor

Mary K Hayden

Last update posted

Oct 15, 2025

Last verified

Oct, 2025

Keywords

  • Candida auris
  • Decolonization
  • Colonization
  • Infection Prevention
  • Povidone Iodine
  • Long-term Care

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Mary K Hayden on 2025-10-15.