Recruiting

Running Locking Suture vs. Standard Running Suture

Sponsor:

UCLA

Code:

NCT06288009

Conditions

Scarring

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Running locking suture

Standard running suture

Study Details

Brief summary:

When patients have surgery on the head and face, stitches are the standard way to close the wound. Wounds always result in a scar, but doctors are always looking for ways to reduce scarring. Several studies have been done to test ways to close wounds that reduce scarring. The most commonly performed closure technique uses running sutures, where a single strand of suture is continued along the length of the wound with a series of uninterrupted stiches. However, alternative closure techniques exist such as the running locking suture, which can offer advantages such as improved tension and thus reduce post-operative complications with better aesthetic outcome. In this study, half the wound will be stitched with standard running sutures and the other half will be stitched with running locking sutures. This will allow us to see if the side with running locking sutures heals with less scarring.

Conditions

Scarring

Study ID

NCT06288009

Start date

Aug 1, 2024

Status verified date

Dec, 2025

Completion date

Oct 1, 2026

Anticipated

Primary completion date

Aug 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 18 years of age or older
  • Able to give informed consent themselves
  • Patient scheduled for cutaneous surgical procedure on the head or neck with predicted primary closure
  • Willing to return for follow up visit

Exclusion Criteria:

  • Incarceration
  • Under 18 years of age
  • Pregnant Women
  • Unable to understand written and oral English
  • Wounds with predicted closure length less than 3cm

Study Design

Enrollment

50 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Layered Closure with Running Locking Suture on Side A

For all participants, one wound side half will be labeled as A and the other side as B. The bottom (subcutaneous) layer of the entire wound will receive the normal stitching. For the upper (cutaneous) layer, Side A will be closed with a running locking suture, and Side B will be closed with a standard running suture.

experimental: Layered Closure with Running Locking Suture on Side B

For all participants, one wound side half will be labeled as A and the other side as B. The bottom (subcutaneous) layer of the entire wound will receive the normal stitching. For the upper (cutaneous) layer, Side B will be closed with a running locking suture, and Side A will be closed with a standard running suture.

Interventions

Running locking suture

In running locking sutures, the first anchoring knot is made at one end of the wound, and a loop of suture is left from the beginning of the throw. The needle is then passed through the loop of suture, locking the suture in place. This is repeated until reaching the end of the wound, where the suture material is then tied to the loop using an instrument tie for the final throw.

Standard running suture

In standard running sutures, the first anchoring knot is made at one end of the wound, and all of the suture material is pulled through after completing the throw. This is repeated until reaching the end of the wound, where the suture material is then tied.

Primary outcome measure

  • Observer Scar Assessment as measured by Patient Observer Scar Assessment Score (POSAS) [ Time Frame: 3 months ]

Central Contacts and Locations

Central contacts

Locations

University of California, Davis - Dermatology Department

Recruiting

Sacramento, California, United States, 95816

Contacts

Principal Investigator:

Daniel Eisen, MD

More Information

Sponsor

University of California, Davis

Last update posted

Dec 5, 2025

Last verified

Dec, 2025

Keywords

  • Running Locking Suture

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, Davis on 2025-12-05.