Recruiting

eTMS

Sponsor:

Virginia Polytechnic Institute and State University

Code:

NCT06294106

Conditions

Post Traumatic Stress Disorder

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)

Study Details

Brief summary:

A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.

Conditions

Post Traumatic Stress Disorder

Study ID

NCT06294106

Start date

Jun 10, 2024

Status verified date

Jun, 2026

Completion date

Sep, 2028

Anticipated

Primary completion date

Jun, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Veteran or first responder
  • diagnosed with post-traumatic stress disorder with PCL-5 cutoff of 31 or above

Exclusion Criteria:

  • Claustrophobia
  • Contraindications to MRI
  • Pregnant
  • Uncontrolled medical, psychological, or neurological conditions
  • Unable to calculate EEG alpha frequency
  • History of ECT or rTMS
  • History of intracranial lesion or increased intracranial pressure
  • History of stroke
  • History of other neurologic conditions
  • Family history of epilepsy
  • Personal history of epilepsy
  • certain medications

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: eTMS

The active side of a TMS coil will be used to administer eTMS application.

sham comparator: eTMS sham

The sham side of a TMS coil will be used to administer a sham dosage of eTMS application.

Interventions

Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)

EEG is utilized to determine a personalized frequency to then apply TMS to the frontal lobe.

Primary outcome measure

  • Adverse Events [ Time Frame: Up to 7 weeks ]
  • Report of Symptoms [ Time Frame: Up to 7 weeks ]

Central Contacts and Locations

Central contacts

Jessica Florig, MPH

540-526-2261jnw@vtc.vt.edu

Locations

Fralin Biomedical Research Institute

Recruiting

Roanoke, Virginia, United States, 24016

Contacts

Jessica Florig, MPH

540-526-2261jnw@vtc.vt.edu

Principal Investigator:

Wynn Legon, PhD

More Information

Sponsor

Virginia Polytechnic Institute and State University

Last update posted

Jul 2, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Virginia Polytechnic Institute and State University on 2026-07-02.