Recruiting

Overdose Prevention

Sponsor:

Johns Hopkins Bloomberg School of Public Health

Code:

NCT06327061

Conditions

Drug Overdose

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Network overdose prevention

Standard of care health education

Study Details

Brief summary:

The purpose of this study is to test a social intervention focused on overdose prevention and care. In the investigators prior work, the investigators have shown that people who use opioids (PWUO) can be effective peer educators (PEs).

Conditions

Drug Overdose

Study ID

NCT06327061

Start date

Jun 1, 2024

Status verified date

Mar, 2026

Completion date

Apr 1, 2029

Anticipated

Primary completion date

Apr 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • self-reported illicit opioid use at least 2 times in the past two weeks;
  • age 18 and older;
  • living in the Baltimore metropolitan region;
  • willing to engage in peer education; and
  • having and willing to recruit at least one non-using network member.

Exclusion Criteria:

Participants without the cognitive ability to provide informed consent and have the physical ability to participate in in-person intervention sessions.

Study Design

Enrollment

600 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Experimental: Peer education and network support

During sessions 1 and 2, participants will be taught information and skills pertaining to overdose prevention and response. During the 3rd session, participants will trained to talk to their non drug using network members in overdose prevention and response.

active comparator: comparison: Standard of care of health education

In one session, participants will receive the standard of care for overdose prevention.

Interventions

Network overdose prevention

Participants are taught overdose prevention methods with network members.

Standard of care health education

Participants will receive the standard of care for overdose prevention.

Primary outcome measure

  • Number of drug overdoses [ Time Frame: 3-months ]
  • Participant drug use [ Time Frame: 3-months ]

Central Contacts and Locations

Central contacts

Carl Latkin, PhD

(410)955-3972carl.latkin@jhu.edu

Locations

Johns Hopkins Bloomberg School of Public Health

Recruiting

Baltimore, Maryland, United States, 21205

Contacts

Carl Latkin, PhD

410-955-3972clatkin@jhsph.edu

Principal Investigator:

Carl Latkin, PhD

More Information

Sponsor

Johns Hopkins Bloomberg School of Public Health

Last update posted

Mar 4, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins Bloomberg School of Public Health on 2026-03-04.