Recruiting

Zinc & Iron

Sponsor:

UCLA

Code:

NCT06327529

Conditions

Zinc Absorption

Iron Absorption

Eligibility Criteria

Sex: Female

Age: 19 - 24

Healthy Volunteers: Accepted

Interventions

SER 118

LMP 1001

LPA 586

KAT B1

Study Details

Brief summary:

Fifteen female study participants will be enrolled in a randomized crossover study to measure fractional and total zinc and iron absorption from four common bean (Phaseolus vulgaris) varieties with varying phytate and polyphenolic contents. Phytate, the storage form of phosphorus in plants, and polyphenols, which contribute to the varied colors of common beans, are natural components of the beans and can reduce zinc and iron bioavailability from these foods.

Conditions

Zinc Absorption

Iron Absorption

Study ID

NCT06327529

Start date

May 1, 2024

Status verified date

Feb, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 19 - 24

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy eumenorrheic (regular monthly menstrual cycles of 25-30-days in length)
  • BMI 18.5 - 30 kg/m2
  • Regular consumer of beans, i.e. ≥ 4 servings per month
  • Usual iron intake estimated by Food Frequency Questionnaire to be less than the Recommended Daily Allowance (RDA) of 18 mg/d (8)
  • Subject is willing and able to comply with the study protocols.
  • Subject is willing to participate in all study procedures.

Exclusion Criteria:

  • Dislike or allergy to beans
  • Self-reported current or recent pregnancy (within the past 12 months)
  • Self-reported recent termination of pregnancy (3 months if abortion in 1st or 2nd trimester, or 12 months if in 3rd trimester)
  • Self-reported plans to become pregnant during the study period
  • Self-reported cancer
  • Self-reported surgery without the past 12 months
  • Currently taking prescription drugs, other than for contraception, or any nutritional supplements
  • Any daily iron supplementation within the past 12 months.
  • Currently breastfeeding
  • Any medical conditions affecting iron or zinc metabolism (such as hemochromatosis or sickle cell disease)

Study Design

Enrollment

15 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Bean Variety 1

Enriched with Zinc-67, Iron-57

experimental: Bean Variety 2

Enriched with Zinc-70, Iron-58

experimental: Bean Variety 3

Enriched with Zinc-67, Iron-57

experimental: Bean Variety 4

Enriched with Zinc-70, Iron-58

Interventions

SER 118

Bean High in Phytic Acid and High in Inhibitory Polyphenols

LMP 1001

Bean Low in Phytic Acid and High in Inhibitory Polyphenols

LPA 586

Bean Low in Phytic Acid and Low in Inhibitory Polyphenols

KAT B1

Bean High in Phytic Acid and Low in Inhibitory Polyphenols

Primary outcome measure

  • Fractional Zinc absorption [ Time Frame: 24 hours after first intake ]
  • Fractional Iron absorption [ Time Frame: 24 hours after first intake ]

Central Contacts and Locations

Central contacts

Roberta R Holt, PhD

530-400-5952rrholt@ucdavis.edu

Locations

Department of Nutrition

Recruiting

Davis, California, United States, 95616

Contacts

Roberta R Holt, PhD

530-752-4950rrholt@ucdavis.edu

More Information

Sponsor

University of California, Davis

Last update posted

Feb 20, 2026

Last verified

Feb, 2026

Keywords

  • zinc
  • iron
  • absorption
  • phytate
  • polyphenols
  • beans

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, Davis on 2026-02-20.