Recruiting

Radiation Therapy & Collagenase

Sponsor:

Dartmouth-Hitchcock Medical Center

Code:

NCT06330545

Conditions

Dupuytren Contracture

Eligibility Criteria

Sex: All

Age: 45+

Healthy Volunteers: Accepted

Interventions

Radiation therapy

Study Details

Brief summary:

The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are:

• Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum?

Participants will undergo:

  • Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection
  • Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy

Conditions

Dupuytren Contracture

Study ID

NCT06330545

Start date

Sep 16, 2024

Status verified date

Jul, 2026

Completion date

Apr, 2032

Anticipated

Primary completion date

Apr, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 45+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 45 or greater with DC
  • Extension deficit >10 degrees
  • Unable to simultaneously place the affected finger and palm flat on a table.
  • Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
  • For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included

Exclusion Criteria:

  • Unsuccessful non-surgical release (> N/1 disease)
  • They develop an open wound during CCH
  • Breast feeding or pregnancy
  • A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
  • Less than the age of 45
  • They have previously undergone radiation on the hand in which they plan to get CCH injections
  • They are pregnant women, impaired adults or prisoners

Study Design

Enrollment

95 participants

Anticipated

Intervention Model

Single group

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Patients with Dupuytren's Contacture

Patients with Dupuytren's Contacture will undergo Collagenase Clostridium Histolyticum injection and release followed by two 5-day courses of radiation therapy separated by 6-8 weeks. They will then be followed for 3 years for recurrence.

Interventions

Radiation therapy

Patients with Dupuytren's Contacture will undergo Collagenase Clostridium Histolyticum injection and release followed by two 5-day courses of radiation therapy separated by 6-8 weeks. They will then be followed for 3 years for recurrence.

Primary outcome measure

  • Recurrence of Dupuytren's Contracture [ Time Frame: one month, 6 months, 12 months, 24 months, and 36 months post-radiation treatment ]

Central Contacts and Locations

Central contacts

Peter A DePalo, BS, CCRP

603 653-0494peter.a.depalo.sr@hitchcock.org

Lance Warhold, MD

603 650-5133

Locations

Dartmouth Hitchcock

Recruiting

Lebanon, New Hampshire, United States, 03766

Contacts

Julia Schwarz, MD

6036505133julia.s.schwarz@hitchcock.org

More Information

Sponsor

Dartmouth-Hitchcock Medical Center

Last update posted

Jul 28, 2026

Last verified

Jul, 2026

Keywords

  • Dupuytren's contracture
  • radiation therapy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Dartmouth-Hitchcock Medical Center on 2026-07-28.