OCP PharmacogenomicsOral Contraceptive Pill (OCP) Pharmacogenomics

Inclusion Criteria:

1. Provision of signed and dated informed consent form
2. Stated willingness to comply with all study procedures and availability for the duration of the study
3. Female, aged 18-45 years old
4. In good general health as evidenced by medical history and no need for regular intensive medical interventions (e.g., inpatient admissions, surgical treatments). The Principal Investigator will be responsible for determining good general health for potential participants with complicated medical histories.
5. Ability to take oral medication and be willing to adhere to the oral contraceptive pill (DSG/EE) regimen
6. Body-mass index ≥18.5kg/m2
7. Willing to abstain from medications and supplements known to induce/inhibit CYP3A (e.g., rifampin, carbamazepine, ketoconazole, St. John's wort) during the study
8. Normal blood pressure measurement at study screening
9. Negative urine pregnancy test at study screening

Exclusion Criteria:

1. Currently taking any known CYP3A inducers/inhibitors (e.g., rifampin, carbamazepine, ketoconazole, St. John's wort)43
2. Any medical conditions that affect liver function (e.g., hepatitis, cirrhosis)
3. Contraindications to estrogen-containing contraception (based on category 3 or 4 recommendations in the CDC MEC guidelines42)

1. Current breast cancer or personal history of breast cancer
2. Severe decompensated cirrhosis
3. Personal history of deep venous thrombosis or pulmonary embolism
4. Recent major surgery with prolonged immobilization
5. Diabetes with nephropathy, retinopathy, neuropathy, or other vascular disease
6. Current gallbladder disease
7. Migraine headaches with aura
8. History of malabsorptive bariatric surgery
9. History of cholestasis due to past oral contraceptive pill use
10. Personal history of hypertension
11. Personal history of ischemic heart disease
12. Known thrombogenic mutations
13. Personal history of focal nodular hyperplasia of the liver, hepatocellular adenoma, or malignant hepatoma
14. Multiple sclerosis with prolonged immobility
15. History of peripartum cardiomyopathy
16. Current tobacco smoker and age ≥35 years
17. History of complicated solid organ transplantation
18. Personal history of stroke
19. Personal history of superficial venous thrombosis
20. Systemic lupus erythematosus with positive or unknown antiphospholipid antibodies
21. Complicated valvular heart disease
22. Current use of fosamprenavir or lamotrigine
4. Use of injectable contraceptive method within 6 months or current use of an ENG implant
5. Childbirth within 6 months