Recruiting

Propofol

Sponsor:

Ciusss de L'Est de l'Île de Montréal

Code:

NCT06346158

Conditions

Anesthesia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Cognitive testing

electroencephalogram

High density electroencephalogram

General anesthesia

Study Details

Brief summary:

The goal of this observational study is to explore the variability of the concentration at the effect site (Ce) of propofol to reach deep anesthesia (DA) during induction of general anesthesia in adults.

The investigators hypothesized that there is a great variability in this Ce that could be precisely explained by

  • Electroencephalographic (EEG) features available prior to induction of anesthesia
  • Cognitive performance
  • Patients characteristics Participants will undergo preoperative cognitive testing and awake EEG. Then, induction of general anesthesia will be performed using continuous infusion of propofol. The Ce at which Deep anesthesia is observed will be recorded.

Conditions

Anesthesia

Study ID

NCT06346158

Start date

Apr 7, 2025

Status verified date

Dec, 2025

Completion date

Jan, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Scheduled for any kind of surgery under general anesthesia.
  • Adults

Exclusion Criteria:

  • Inability to communicate in French or English,
  • Known allergy or intolerance or other medical condition that precludes the use of prescribed general anesthesia protocol for this study,
  • Patients requiring rapid sequence induction,
  • Anticipated or known difficult intubation patient,
  • Anticipated or known difficult ventilation patient,
  • Body mass index ≥ 35 kg.m-2.

Study Design

Enrollment

110 participants

Anticipated

Interventions and Outcome Measures

Interventions

Cognitive testing

Preoperative cognitive battery test

electroencephalogram

Preoperative 24 channel EEG

High density electroencephalogram

preoperative 128-channel electroencephalogram

General anesthesia

induction of general anesthesia using propofol 1%

Primary outcome measure

  • Concentration at the effect-site propofol associated with deep anesthesia (CeDA) [ Time Frame: during surgery ]

Central Contacts and Locations

Central contacts

Louis Morisson, MD, MSc

514-252-3400louis.morisson@umontreal.ca

Nadia Godin, RN

514-252-3400nadia.godin.hmr@ssss.gouv.qc.ca

Locations

Hopital Maisonneuve-Rosemont

Recruiting

Montreal, Quebec, Canada, H1T 2M4

Contacts

Nadia Godin, RN

514-252-3400ngodin.hmr@ssss.gouv.qc.ca

Principal Investigator:

Louis Morisson, M.D., M.Sc.

More Information

Sponsor

Ciusss de L'Est de l'Île de Montréal

Last update posted

Jan 16, 2026

Last verified

Dec, 2025

Keywords

  • general anesthesia
  • propofol
  • interindividual variability
  • prediction
  • cognitive performance
  • electroencephalogram

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Ciusss de L'Est de l'Île de Montréal on 2026-01-16.