Recruiting

Linoleic Acid

Sponsor:

Ohio State University

Code:

NCT06361511

Conditions

Sarcopenia

Eligibility Criteria

Sex: All

Age: 65 - 70+

Healthy Volunteers: Not accepted

Interventions

High Linoleic Acid Foods

High Oleic Acid Foods

Study Details

Brief summary:

The proposed research is a parallel arm, randomized placebo-controlled clinical trial designed to assess changes in muscle strength, volume, fatigue resistance, and mobility in older adults after daily consumption of 12g of linoleic acid-rich oil.

Conditions

Sarcopenia

Study ID

NCT06361511

Start date

Apr 16, 2025

Status verified date

Apr, 2026

Completion date

May 1, 2030

Anticipated

Primary completion date

May 1, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 65 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Linoleic Acid Intake <75% of the adequate intake
  • Probable sarcopenia

Exclusion Criteria:

  • Gastrointestinal diseases or disorders (including pancreatic and gastric bypass surgery) where consumption of the study foods would be contraindication or where the disease or disorder could negatively affect nutrient absorption and/or would prevent participants from tolerating the study foods
  • Hyperthyroidism diagnosis
  • Food Allergy or intolerances
  • Any dietary restriction where consumption of the study foods or any ingredient would be contraindicated
  • Unstable management of heart failure, heart disease events (including stroke or heart attack) within last 3 months prior to enrollment, a plan for heart surgeries or cardiac procedures
  • Current or previous diagnosis of severe kidney failure, liver cirrhosis, other liver diseases/infections that cause liver damage and some pulmonary diseases or severe/uncontrolled pulmonary diseases
  • Severe or uncontrolled rheumatologic or orthopedic diseases
  • Current diagnosis of or current treatment of cancer other than non-melanoma skin cancer
  • Neuromuscular or neurological conditions or diseases or use of mobility assistance (wheelchair, walker etc..) that would impact movement needed to perform the muscle function tests or prevent completion of the muscle function tests
  • Use of mobility assistance (wheelchair, walker etc..) that would prevent completion of the muscle function tests
  • Current use of supplements or medications for weight loss or following a weight loss program
  • Use of supplements high in linoleic acid in the past 4 weeks prior to enrolling
  • Pregnancy and lactation
  • Alcohol or drug abuse
  • Allergy/intolerance to lidocaine or similar medication
  • Use of anticoagulant, antiplatelet, or other blood thinner medications
  • Terminal Illness
  • Any condition leading to muscle loss or weakness, impaired mobility or range of motion in legs (excluding normal aging)

Study Design

Enrollment

66 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: High Linoleic Safflower Oil

consumption of 12g of high linoleic safflower oil every day

placebo comparator: High Oleic Safflower Oil

Consumption of 12g of high oleic safflower oil every day

Interventions

High Linoleic Acid Foods

Two food products containing 6g of high linoleic safflower oil each will be consumed each day for a total of 12g daily

High Oleic Acid Foods

Two food products containing 6g of high oleic safflower oil each will be consumed each day for a total of 12g daily

Primary outcome measure

  • Changes is leg extensor muscle strength [ Time Frame: Week 0 and Week 24 ]

Central Contacts and Locations

Central contacts

Martha Belury, PhD RDN

614-292-1680belury.1@osu.edu

Rachel Cole

614-247-8235belurylabstudies@osu.edu

Locations

The Ohio State University

Recruiting

Columbus, Ohio, United States, 43210

Contacts

Martha Belury, PhD

614-292-1680belury.1@osu.edu

More Information

Sponsor

Ohio State University

Last update posted

Apr 21, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Ohio State University on 2026-04-21.