Recruiting

Resistance Exercise

Sponsor:

University of Utah

Code:

NCT06366399

Conditions

Diabetes Mellitus, Type 2

Insulin Resistance

Glucose Intolerance

Sleep Disturbance

Overweight or Obesity

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Not accepted

Interventions

Resistance Exercise Timing

Study Details

Brief summary:

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

Conditions

Diabetes Mellitus, Type 2

Insulin Resistance

Glucose Intolerance

Sleep Disturbance

Overweight or Obesity

Study ID

NCT06366399

Start date

Nov 15, 2023

Status verified date

Mar, 2025

Completion date

Dec 31, 2025

Anticipated

Primary completion date

Dec 31, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Men and women, all ethnicities, aged 50-74 years
  • BMI ≥25 kg/m² and <45 kg/m²
  • Weight stable (less than 5% change in the past 6 months)
  • Generally healthy individuals
  • Not meeting recommended activity guidelines for aerobic or resistance exercise

Exclusion Criteria:

  • Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease
  • Cancer treatment in the past 5 years
  • Untreated thyroid disease or other medical conditions affecting weight or energy metabolism
  • Current use of weight loss medication or other medications likely to impact energy balance
  • Bariatric surgery or extensive bowel resection in the past 2 years
  • Current or recent history (past 2 years) of eating disorder
  • Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders
  • Non-English speaking
  • HbA1c >6.5%

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: AM Resistance Exercise

Resistance Exercise intervention taking place in the AM

experimental: PM Resistance Exercise

Resistance Exercise intervention taking place in the PM

Interventions

Resistance Exercise Timing

1 resistance exercise session consisting of 3 sets, 10 repetitions per set, on 12 different exercises

Primary outcome measure

  • Insulin sensitivity [ Time Frame: 1 day ]

Central Contacts and Locations

Central contacts

Tanya M Halliday, PhD

801-213-1364tanya.halliday@utah.edu

Study Email Study Email

8014487897trexstudy@utah.edu

Locations

University of Utah HPER E Buildling

Recruiting

Salt Lake City, Utah, United States, 84112

Contacts

Jason V Thomas, MS

jason.v.thomas@utah.edu

Principal Investigator:

Tanya M Halliday, PhD

More Information

Sponsor

University of Utah

Last update posted

Apr 3, 2025

Last verified

Mar, 2025

Keywords

  • Resistance Exercise
  • Strength-training
  • Sleep
  • Circadian Rhythm

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Utah on 2025-04-03.