Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT06370780

Conditions

HIV Infections

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

EPI LOVE

Study Details

Brief summary:

Despite the widespread availability of effective antiretroviral therapy (ART) in the United States, there remains significant numbers of people living with HIV (PLWH) who fail to achieve and or maintain viral suppression (VS). Disparities persist with the lowest levels of VS among Black individuals, people who use drugs, youth ages 18-24 and people residing in rural areas. Investigators will examine the syndemics underlying these outcomes including substance use, mental health, and barriers to HIV care including racial discrimination, stigma and rural isolation.

Conditions

HIV Infections

Study ID

NCT06370780

Start date

Feb 9, 2024

Status verified date

Sep, 2025

Completion date

Apr 30, 2028

Anticipated

Primary completion date

Apr 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Have access to a personal smartphone device;
  • Over 18 years of age;
  • Speak English or Spanish;
  • Living with HIV
  • Are either 1) not currently virally suppressed, 2) not currently engaged in care, or 3) have one or more factors associated with viral non suppression including a history of missed appointments or viral non suppression;
  • Active substance use or mental health disorder;
  • Willing and able to provide written informed consent to take part in the study.

Exclusion Criteria:

  • Unwilling or unable to provide reliable contact information;
  • Unwilling to provide blood sample for HIV virology testing;
  • Living with HIV and virally suppressed and not at risk of becoming unsuppressed in the near future.

Study Design

Enrollment

1000 participants

Anticipated

Intervention Model

Single group

Primary purpose

Other

Interventions and Outcome Measures

Arms

other: Download the REMAIN App

All participants download the app

Interventions

EPI LOVE

Observational cohort only

Primary outcome measure

  • Incidence of HIV Viral Suppression [ Time Frame: past 3 months ]
  • Level of Adherence to HIV medication [ Time Frame: past 6 months ]
  • Level of Adherence based on HIV appointments [ Time Frame: one year ]

Central Contacts and Locations

Central contacts

Pamina Gorbach, DrPh

(628) 226-1863RemainApp@ph.ucla.edu

Valerie El-Alfi, MA

RemainApp@ph.ucla.edu

Locations

University of California, Los Angeles

Recruiting

Los Angeles, California, United States, 90095

Contacts

Pamina Gorbach, DrPh, MHS

(628) 226-1863RemainApp@ph.ucla.edu

Valerie El-Alfi, MA

RemainApp@ph.ucla.edu

More Information

Sponsor

University of California, Los Angeles

Last update posted

Oct 3, 2025

Last verified

Sep, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2025-10-03.