Recruiting

Observational Study

Sponsor:

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Code:

NCT06371937

Conditions

Cardiovascular Diseases

Arrythmia

Cardiomyopathies

Heart Failure

Cerebrovascular Accident

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The Investigators will create a clinical database and a Biobank of stem cells derived from the blood of participants with cardiovascular disease. The Investigators will recruit participants from diverse racial and ethnic backgrounds with equal representation from both sexes. The Investigators expect to create stem cells and analyze the blood for protein biomarkers and genetic causes of cardiovascular disease. The stem cell biobank and clinical data will be a powerful tool for studying cardiovascular disease.

Conditions

Cardiovascular Diseases

Arrythmia

Cardiomyopathies

Heart Failure

Cerebrovascular Accident

Study ID

NCT06371937

Start date

May 1, 2024

Status verified date

May, 2024

Completion date

Jun 30, 2033

Anticipated

Primary completion date

Jun 30, 2033

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adult (18 to 80 years of age)
  • Cardiovascular Disease (CVD)
  • Cerebrovascular Disease (CBD)
  • Peripheral Vascular Disease (PVD)
  • Inherited Arrhythmias
  • Cardiomyopathies
  • Congenital Heart Disease (CHD)
  • Aortopathy
  • Hypertension
  • Cardiometabolic Disease (CMD)

Exclusion Criteria:

  • Younger than 18 years of age.
  • Patients not able to provide consent.

Study Design

Enrollment

200 participants

Anticipated

Interventions and Outcome Measures

Arms

study controls

Healthy control participants (n=50) aged 80 and older enrolled in the study with no known CVD or history of significant medical problems.

cardiovascular disease

Participants with cardiovascular disease (n=150)

Primary outcome measure

  • REDCap Database [ Time Frame: 10 years ]
  • Induced pluripotent stem cell (iPSC) Biobank [ Time Frame: 10 years ]
  • Differentiation into Cardiovascular lineages [ Time Frame: 10 years ]
  • Molecular profiling of participants [ Time Frame: 10 years ]
  • Bioinformatics analysis [ Time Frame: 10 years ]

Central Contacts and Locations

Locations

London Regional Health Science Centre

Recruiting

London, Ontario, Canada, N6A 5A5

Contacts

Mark Chandy, MD PhD

5196612111mark.chandy@lhsc.on.ca

More Information

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Last update posted

May 29, 2024

Last verified

May, 2024

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's on 2024-05-29.