Recruiting

Theta Burst TMS

Sponsor:

Carilion Clinic

Code:

NCT06372288

Conditions

Methamphetamine Abuse

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

Transcranial Magnetic Stimulation

Sham Transcranial Magnetic Stimulation

Study Details

Brief summary:

This study is using Transcranial Magnetic Stimulation (TMS) to determine if interventional psychiatry treatment can help with the treatment of Methamphetamine Use Disorder. Individuals with Methamphetamine Use Disorder will receive 5 consecutive TMS treatment sessions based off of randomization. Participants will be randomized to one of two groups. TMS treatment arm or sham-TMS arm.

Conditions

Methamphetamine Abuse

Study ID

NCT06372288

Start date

Dec 20, 2023

Status verified date

Apr, 2024

Completion date

Dec, 2025

Anticipated

Primary completion date

Dec, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Individuals actively struggling with Methamphetamine Use Disorder
  • Must be currently enrolled in Carilion Clinic Office Based Addiction Treatment (OBAT) program

Exclusion Criteria:

- Individuals currently struggling with alcohol use and/or benzodiazepine use

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Transcranial Magnetic Stimulation (TMS)

This arm receives the TMS treatments.

sham comparator: Sham-TMS

This arm receives sham TMS treatments.

Interventions

Transcranial Magnetic Stimulation

Transcranial Magnetic Stimulation (TMS using Intermittent theta burst stimulation (iTBS)

Sham Transcranial Magnetic Stimulation

Participants will not receive intermittent theta burst stimulation during the sham-TMS sessions

Primary outcome measure

  • Stimulant Craving Questionnaire (STCQ) [ Time Frame: Baseline/Visit 2, daily during iTBS/Sham-TMS, 3 days after-, 1 week after-, 2 weeks-after, and one month after completion of iTBS/Sham TMS ]
  • Urine Drug Screen (UDS) [ Time Frame: Baseline/Visit 2, day 5 of iTBS/Sham TMS, 3 days after-, 1 week after-, 2 weeks-after, and one month after completion of iTBS/Sham TMS ]

Central Contacts and Locations

Central contacts

Sooraj John, M.D.

540-981-7000research@carilionclinic.org

Maryann Hollen, B.S.

540-566-8081research@carilionclinic.org

Locations

Carilion Clinic

Recruiting

Roanoke, Virginia, United States, 24014

Contacts

Maryann Hollen, B.S.

540-566-8081

More Information

Sponsor

Carilion Clinic

Last update posted

Apr 26, 2024

Last verified

Apr, 2024

Keywords

  • Transcranial Magnetic Stimulation (TMS)
  • methamphetamine use disorder

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Carilion Clinic on 2024-04-26.