Recruiting

Cognitive Training

Sponsor:

University of Wisconsin, Madison

Code:

NCT06375681

Conditions

Cognitive Change

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Visual and / or Auditory Cognitive Tasks (1)

Visual and / or Auditory Cognitive Tasks (2)

Study Details

Brief summary:

The proposed study will enroll 1600 participants to examine the effectiveness of cognitive training. Participants will be randomized into different experimental groups and can expect to participate for up to 15 hours of research over 4 to 8 weeks.

Conditions

Cognitive Change

Study ID

NCT06375681

Start date

Apr 1, 2025

Status verified date

Apr, 2026

Completion date

Jul, 2027

Anticipated

Primary completion date

May, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Self-reported normal or corrected-to-normal vision
  • No known neurological impairments
  • Age within inclusion range (18-30 Years for Younger Adults and 60-85 Years for Older Adults)

Exclusion Criteria

  • Physical handicap (motor or perceptual) that would impede training procedures
  • Concurrent enrollment in other cognitive training studies
  • Not being proficient enough in English that would prevent following and understanding all instructions and completing all testing sessions (typically, participants would need to have learned English before age 11; there might be some exceptions that will be decided on a case-by-case basis).
  • Unable to adhere to training schedule

Additional exclusion criteria for older adults:

\- Score < 17 (out of 22) on the Telephone Montreal Cognitive Assessment (T-MoCA).

Study Design

Enrollment

1600 participants

Anticipated

Allocation

Randomized

Intervention Model

Factorial

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

active comparator: Short Testing Group

Participants will go through 2 assessment sessions over 2-3 days (\~75 minutes each), followed by 1 session of 75 minutes about 2 weeks later, 2 further sessions (\~75 minutes) over 2-3 days about 2 weeks after this session, and finally another 2 sessions (\~45 minutes) 3 days to 2 weeks after that session. Sessions might take place either at home or in the lab.

active comparator: Long Testing Group

Participants will go through 2 assessment sessions over 2-3 days (75 minutes each), followed by 10 sessions of cognitive tasks over 2 weeks, 1 session of 75 minutes about 2 weeks later, another 10 sessions of cognitive tasks over 2 weeks, then 2 sessions (\~75 minutes) over 2-3 days about 2 weeks after this session, and finally another 2 sessions (\~45 minutes) 3 days to 2 weeks after that session. Sessions might take place either at home or in the lab.

Interventions

Visual and / or Auditory Cognitive Tasks (1)

Seven sessions (\~45-75 minutes) of cognitive tasks in the lab.

Participants asked to view visual stimuli (such as black and white lines, letters, simple shapes like triangles, circles, and squares) presented on a computer or television screen and/or listen to auditory stimuli (such as pure tones) presented via headphone or speakers and asked to make simple judgements.

Visual and / or Auditory Cognitive Tasks (2)

Two sets of 10 sessions (\~20 minutes) of cognitive tasks either at home or in the lab.

Participants asked to view visual stimuli (such as black and white lines, letters, simple shapes like triangles, circles, and squares) presented on a computer or television screen and/or listen to auditory stimuli (such as pure tones) presented via headphone or speakers and asked to make simple judgements.

Primary outcome measure

  • Change in the difference between the proportion of hits minus false alarms for a given level of the N-back task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the proportion of correctly reported sequences in the Corsi Complex task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the proportion of correctly reported number and letter sets in the Letter-Number task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the difference of response time and accuracy in switch trials minus non-switch trials in the Task Switching Task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the difference of response time in (i) switch trials minus non-switch trials and (ii) congruent minus incongruent trials in the Flanker Task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the proportion of correctly identified targets in the mixed condition of the Cancellation task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the proportion of correct responses on the Useful Field of View (UFOV) Task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the proportion of correct responses on the Multiple Object Tracking (MOT) Task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the response time and percentage of correct responses in the Mental Rotation Task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the percentage of correct responses in the Paper Folding task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the sum of correctly solved items in Raven's Advanced Progressive Matrices task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the sum of correctly solved items in the UC Matrix Reasoning task [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the percentage of accuracy in the Shipley Institute of Living Scale [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]
  • Change in the percentage of accuracy in the Mill-Hill Vocabulary Scale [ Time Frame: Pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days ]

Central Contacts and Locations

Central contacts

C. Shawn Green, PhD

(608) 263-4868cshawn.green@wisc.edu

Freya Joessel, PhD

joessel@wisc.edu

Locations

University of California, Riverside

Recruiting

Riverside, California, United States, 92521

Contacts

Aaron Seitz, PhD

951-827-6422aseitz@ucr.edu

Northeastern University

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Susanne Jaeggi, PhD

617-373-3653s.jaeggi@northeastern.edu

University of Wisconsin - Madison

Recruiting

Madison, Wisconsin, United States, 53706

Contacts

C. Shawn Green, PhD

608-263-4868cshawn.green@wisc.edu

More Information

Sponsor

University of Wisconsin, Madison

Last update posted

May 29, 2026

Last verified

Apr, 2026

Keywords

  • Cognitive Training
  • Training task
  • Testing context

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Wisconsin, Madison on 2026-05-29.