Recruiting

Raman Spectroscopy

Sponsor:

Tiezhi Zhang

Code:

NCT06384924

Conditions

Skin Cancer

Basal Cell Carcinoma

Squamous Cell Carcinoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Raman Spectroscopy handheld probe (EmVision, FL, USA)

Raman Spectroscopy laser source (Hubner Photonics Inc, CA, USA)

Study Details

Brief summary:

The goal of this observational study is to find out if Raman Spectroscopy, a type of imaging, can be used to determine the size of skin cancer tumors. The main question it aims to answer is:

-Can Raman Spectroscopy help figure out how far a tumor spreads?

This study will take measurements using laser light from an experimental, handheld probe by lightly touching the skin.

Conditions

Skin Cancer

Basal Cell Carcinoma

Squamous Cell Carcinoma

Study ID

NCT06384924

Start date

Feb 13, 2025

Status verified date

Apr, 2026

Completion date

Feb 13, 2027

Anticipated

Primary completion date

Feb 13, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Histologically confirmed skin cancer (either basal cell carcinoma or squamous cell carcinoma)
  • Participants must plan to receive brachytherapy treatment for the skin cancer at the study site.
  • Ability to provide consent to the study.

Exclusion Criteria:

  • Patient belongs to a vulnerable population (Minors (under 18 years old), Adults unable to consent, prisoners).
  • Lesions on the eyelid or in close proximity to the eye
  • Pregnant women, or women of childbearing age who refuse pregnancy testing.
  • Patient has pacemaker.

Study Design

Enrollment

20 participants

Anticipated

Interventions and Outcome Measures

Arms

Raman Spectroscopy

Interventions

Raman Spectroscopy handheld probe (EmVision, FL, USA)

The probe is approximately the size of a pen or pencil. The handheld probe is connected to the laser source using a cable. The probe is placed in light contact with the skin. The features of the laser light after it bounces off the skin is collected. This measurement can allow us to see tissue characteristics. This is a single session that will take approximately 15 minutes.

Raman Spectroscopy laser source (Hubner Photonics Inc, CA, USA)

This light source will create the laser light that will pass through the cable and through the handheld probe onto the skin.

Primary outcome measure

  • Feasibility of Raman Spectroscopy to observe differences in Raman spectra between visible lesion, skin surrounding lesion and contralateral normal skin. [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Tiezhi Zhang

631-444-3617tiezhi.zhang@stonybrookmedicine.edu

Locations

Stony Brook Hospital

Recruiting

Stony Brook, New York, United States, 11794

Contacts

Renee Cattell, PhD

renee.farrell@stonybrookmedicine.edu

Principal Investigator:

Renee Cattell, PhD

More Information

Sponsor

Tiezhi Zhang

Last update posted

May 7, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Tiezhi Zhang on 2026-05-07.