Recruiting

Cannabis Use

Sponsor:

Medical University of South Carolina

Code:

NCT06395389

Conditions

Cannabis Use Disorder

Eligibility Criteria

Sex: All

Age: 18 - 25

Healthy Volunteers: Not accepted

Interventions

Health Education (HealthEdu)

Bloom

Study Details

Brief summary:

The purpose of this study is to compare two brief interventions targeting potentially problematic cannabis use in emerging adults (ages 18-25). Brief interventions are two 40-50 minute sessions separated by 1 week. Eligible emerging adults will complete a detailed cannabis assessment (biological and self-report), followed by one of the two brief interventions, and four follow-up assessments: one immediately after the second session and at 1-, 3-, and 6-months post-intervention. Assignment to the brief intervention is random. Salivary samples will be collected at baseline, post-intervention, and all follow-ups, for a total of 5 samples, to be tested for tetrahydrocannabinol (THC) and cannabidiol (CBD).

Conditions

Cannabis Use Disorder

Study ID

NCT06395389

Start date

Oct 18, 2024

Status verified date

Apr, 2026

Completion date

May, 2029

Anticipated

Primary completion date

May, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 25

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Ages 18-25
2. Self-Report report cannabis use on at least 20 days of the past 30 days
3. Submit a positive urine cannabinoid test

Exclusion Criteria:

1. Currently engaged in substance use treatment for any type of substance use or currently treatment seeking
2. History of substance use treatment for any type of substance
3. Severe alcohol use disorder or indication of any substance use disorder requiring a higher level of care (AUDIT score ≥14 or DUDIT score ≥2 for women, ≥6 for men)
4. Significant or acutely unstable medical or psychiatric problems (i.e., psychosis, mania) that would contraindicate research procedures, interfere with safety, compromise data integrity, or preclude consistent study participation (Screening psychosis score =7)
5. Significant risk of suicide or homicide
6. Currently pregnant or breastfeeding

Study Design

Enrollment

62 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

active comparator: Health Education (HealthEdu)

Brief intervention providing recommendations/advice for good sleep hygiene, nutrition and physical activity, stress, and relationships.

experimental: Bloom

Brief intervention providing personalized discussion of values/goals, reasons for cannabis use, and strategies to help live in line with values and achieve goals.

Interventions

Health Education (HealthEdu)

The Health Education condition is a 2-session brief intervention with each session lasting 40-50 minutes and separated by about 1 week (5-10 days). The first session focuses on providing in-depth information on good sleep hygiene and habits to improve sleep and information on positive eating habits, nutrition, and physical activity/functional exercise. The second session focuses on providing information about stress and social connection.

Bloom

Bloom is a 2-session brief intervention with each session lasting 40-50 minutes and separated by about 1 week (5-10 days). The first session encourages participants to ask themselves what is important to them. This discussion emphasizes identifying values and ways to live in line with their values, as well as why they use cannabis and providing personalized feedback related to their reasons for use. The second session asks participants to reflect on information from session one and consider what they would like to do next to live in line with their values.

Primary outcome measure

  • Timeline Followback (TLFB) [ Time Frame: Baseline, 1-month follow-up, 3-month follow-up, 6-month follow-up ]

Central Contacts and Locations

Central contacts

Kathryn Gex, Ph.D.

(843) 792-4904soltisk@musc.edu

Locations

Medical University of South Carolina

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Kathryn S. Gex, PhD

843-792-4904soltisk@musc.edu

More Information

Sponsor

Medical University of South Carolina

Last update posted

Apr 9, 2026

Last verified

Apr, 2026

Keywords

  • Early intervention
  • Emerging adults

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Medical University of South Carolina on 2026-04-09.