Recruiting

Digital Therapeutics

Sponsor:

UCLA

Code:

NCT06397469

Conditions

Aging

MCI

Cognitive Decline

Eligibility Criteria

Sex: All

Age: 60 - 70+

Healthy Volunteers: Accepted

Interventions

MediTrain

Worder

Study Details

Brief summary:

The goals of the proposed research are to first determine the minimal and/or optimal dose of a digital intervention required for cognitive enhancement, and then to examine the impact of several potential moderators of treatment effects (i.e., cognitive decline, AD polygenic hazard score, cardiovascular risk, and race/ethnicity). This knowledge gained from his high-impact study with transform the field of cognitive interventions, paving the way for a precision medicine model for cognitive enhancing interventions that improve quality of life for older adults and individuals with cognitive deficits at risk of developing dementia.

Conditions

Aging

MCI

Cognitive Decline

Study ID

NCT06397469

Start date

Apr 1, 2024

Status verified date

Aug, 2026

Completion date

Jun 1, 2029

Anticipated

Primary completion date

Jan 1, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 60 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 60+ years old (adult)
  • English language fluency
  • owning a smartphone or tablet

Exclusion Criteria:

  • Under 60 years old (minor)

Study Design

Enrollment

4000 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: MediTrain 30m/day for 6wks

Participants will engage with a digital meditation app for the time listed above.

experimental: MediTrain 15m/day for 6wks

Participants will engage with a digital meditation app for the time listed above.

experimental: MediTrain 30m/day for 3wks

Participants will engage with a digital meditation app for the time listed above.

experimental: MediTrain 15m/day for 3wks

Participants will engage with a digital meditation app for the time listed above.

active comparator: Active Control Group

An active control application will be used for this arm. The total training experience here will be for 6 weeks (5 days/week), with each training session lasting \~30 minutes (not including self-paced breaks). Here an app that is matched in terms of expectancy of benefits compared to our training groups will be determined by questioning 100 naïve individuals to predict their expected improvement on each cognitive domain across a multitude of possible applications.

Interventions

MediTrain

MediTrain is a tablet-based, meditation-inspired, cognitive training game aimed at improving self-regulation of internal attention and distractions. It was developed in collaboration with meditation thought-leader Jack Kornfield, and Zynga, a world-class video game company. It was created to make benefits of concentrative meditation more easily accessible to anyone, including complete novices. This is achieved by creating a game that yields quantifiable and attainable goals, provides feedback, and includes an adaptive algorithm to gradually increase difficulty as users improve.

Worder

Worder was designed to enhance visual motor and visual spatial skills in individuals of all ages and cognitive abilities. Visual processing is required for all cognitive abilities that involve vision including attention, working memory, and task management. Worder's goal is to improve cognitive function more broadly by developing this critical skill underlying multiple abilities.

Primary outcome measure

  • Change on the Mobile Continuous Performance Task (CPT) over time [ Time Frame: baseline, immediate follow-up, and at a 6 month follow-up ]

Central Contacts and Locations

Central contacts

David Ziegler, PhD

4154762164david.ziegler@ucsf.edu

Monique de Villa, MS, MPH

209-233-3878meditrain@ucsf.edu

Locations

University of California San Francisco

Recruiting

San Francisco, California, United States, 94158

Contacts

David Ziegler, PhD

415-476-2164david.ziegler@ucsf.edu

More Information

Sponsor

University of California, San Francisco

Last update posted

Aug 24, 2026

Last verified

Aug, 2026

Keywords

  • healthy aging
  • attention
  • cognition
  • dementia
  • intervention
  • digital
  • behavioral
  • prevention
  • decline
  • stress reduction
  • Quality of life

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-08-24.