Recruiting

Observational Study

Sponsor:

University of Maryland, College Park

Code:

NCT06405594

Conditions

Aphasia, Acquired

Stroke

Healthy Aging

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Language Condition

Study Details

Brief summary:

The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments resulting from stroke have a significant negative impact on quality of life. By seeking to better understand post-stroke aphasia, this project lays the groundwork for development of new interventions, and aligns with NIDCD's priority areas 1 (understanding normal function), 2 (understanding diseases), and 3 (improving diagnosis, treatment, and prevention).

Conditions

Aphasia, Acquired

Stroke

Healthy Aging

Study ID

NCT06405594

Start date

Aug 1, 2024

Status verified date

Aug, 2024

Completion date

Jun, 2029

Anticipated

Primary completion date

Jun, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • At least 18 years of age
  • Persons with acquired aphasia are defined as those with a language impairment following left hemisphere brain injury (most likely a stroke).
  • Neurotypical adults need to be either young (ages 18-30 years) or older (> 60 years)
  • Native (or primary) speakers of English

Exclusion Criteria:

  • Prior neurological or psychiatric diagnoses or developmental disabilities before the onset of aphasia
  • do not speak English fluently

Study Design

Enrollment

350 participants

Anticipated

Intervention Model

Single group

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Language condition

All participants will receive this arm. In this arm, the intervention involves asking participants to speak and understand words and sentences with different linguistic manipulations such as morphological, semantic, phonological priming, predictability of the subject and object nouns associated with verbs, naming of verbs and nouns, production of sentences with past, future or present tense. Accuracy, response times and brain activity are the outcome measures.

Interventions

Language Condition

The intervention involves asking participants to speak and understand words and sentences with different linguistic manipulations such as morphological, semantic, phonological priming, predictability of the subject and object nouns associated with verbs, naming of verbs and nouns, production of sentences with past, future or present tense. Accuracy, response times and brain activity are the outcome measures.

Primary outcome measure

  • Accuracy [ Time Frame: through the completion of the study, an average of 1 year ]
  • Response time [ Time Frame: through the completion of the study, an average of 1 year ]
  • Brain activity [ Time Frame: through the completion of the study, an average of 1 year ]

Central Contacts and Locations

Central contacts

Yasmeen Faroqi-Shah, PhD

3014054229yfshah@umd.edu

Robert Slevc, PhD

(301) 405-5835slevc@umd.edu

Locations

University of Maryland

Recruiting

College Park, Maryland, United States, 20742

Contacts

Yasmeen Faroqi-Shah, PhD

301-405-4229yfshah@umd.edu

Robert Slevc, PhD

(301) 405-5835slevc@umd.edu

More Information

Sponsor

University of Maryland, College Park

Last update posted

Sep 3, 2024

Last verified

Aug, 2024

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Maryland, College Park on 2024-09-03.