Recruiting
Phase 2

Lattice Radiation Therapy

Sponsor:

University of Cincinnati

Code:

NCT06416007

Conditions

Cancer

Metastatic Cancer

Locally Advanced

Locally Advanced Solid Tumor

Locally Advanced Carcinoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Lattice therapy (LRT)

Study Details

Brief summary:

The purpose of this research study is to determine if lattice radiation therapy (LRT) will provide better treatment for bulky (large) tumors than current standard of care radiotherapy.

Conditions

Cancer

Metastatic Cancer

Locally Advanced

Locally Advanced Solid Tumor

Locally Advanced Carcinoma

Study ID

NCT06416007

Start date

Aug 2, 2024

Status verified date

Apr, 2026

Completion date

Jun 1, 2027

Anticipated

Primary completion date

Jan 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Solid tumor malignancy with a clinical indication for radiation
  • Patients must have measurable disease
  • Target lesion(s) which are amenable to lattice therapy plan
  • When applicable, target lesion for radiation amenable to immobilization during delivery of radiotherapy
  • Age ≥18 years.
  • ECOG Performance status ≤2
  • Life expectancy greater than 3 months
  • Women of child-bearing potential and men must agree to avoid conception via abstinence (ideal) or a method of birth control (e.g., hormonal or barrier method of birth control) prior to study entry and for at least 30 days after completion of lattice therapy administration.
  • Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

  • Patients receiving cytotoxic chemotherapy or known radiosensitizing agents within 5 days before or after lattice therapy.
  • Patients with hematologic malignancies including lymphoma and leukemia as well as primary or metastatic central nervous system (CNS) malignancies.
  • Patients with a history of conditions which predispose them to increased radiation toxicity
  • Patients with known contraindications to radiation therapy
  • Patients with uncontrolled intercurrent illness
  • Pregnant women

Study Design

Enrollment

37 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Lattice radiation therapy (LRT)

Lattice radiation therapy (LRT) : 5 fractions

Interventions

Lattice therapy (LRT)

5 Fractions LRT

Primary outcome measure

  • Overall Response Rate [ Time Frame: 60 days post treatment ]
  • Adverse Events [ Time Frame: Up to 60 days post-treatment ]

Central Contacts and Locations

Central contacts

UCCC Clinical Trials Office

513-584-7698cancer@uchealth.com

Locations

University of Cincinnati Medical Center

Recruiting

Cincinnati, Ohio, United States, 45219

More Information

Sponsor

University of Cincinnati

Last update posted

May 4, 2026

Last verified

Apr, 2026

Keywords

  • Radiation
  • Radiotherapy
  • Bulky
  • Spatial fractionation
  • Lattice therapy
  • Palliative
  • Palliation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Cincinnati on 2026-05-04.