Recruiting

Virtual RealityHead-Cancelled Virtual Reality for Ocular Cranial Nerve Palsies

Sponsor:

Kevin Houston

Code:

NCT06417216

Conditions

Internuclear Ophthalmoplegia

Palsy, Abducens

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Head-cancelled virtual reality

Study Details

Brief summary:

This study is investigating whether eye exercises for abducens palsy and internuclear ophthalmoplegia increase ocular range of motion in the paretic direction when performed in virtual reality under head-cancelled compared to head-active conditions.

Conditions

Internuclear Ophthalmoplegia

Palsy, Abducens

Study ID

NCT06417216

Start date

Sep 10, 2024

Status verified date

Apr, 2026

Completion date

Jun 1, 2028

Anticipated

Primary completion date

Jun 1, 2027

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

OCNP Group Inclusion Criteria:

Presence of OCNP in one eye with 50% range-of-motion limitation or worse
Able to provide informed consent and will be able to fluently read and understand spoken English

OCNP Group Exclusion Criteria:

Presence of bilateral OCNP
Range of motion better than 50%
Visual acuity worse than 20/100 in either eye
Greater than 4-line difference in visual acuity between the eyes,
Structural anomalies or sensory sensitivities (e.g. visual motion sensitivity) that would prevent them from wearing or tolerating a VR headset

Participants will be excluded if they are unable to participate if inclusion criteria are not met.

Normal Group Inclusion Criteria:

Absence of OCNP or other neurological or neuro-ophthalmic diseases
No strabismus
Have normal or near-normal vision with glasses or contact lenses.
Be able to provide informed consent and will be able to fluently read and understand spoken English

Normal Group Exclusion Criteria:

Visual acuity worse than 20/100 in either eye
Greater than 4-line difference in visual acuity between the eyes
Structural anomalies or sensory sensitivities (e.g. visual motion sensitivity) that would prevent them from wearing or tolerating a VR headset
Known inability to tolerate visual testing of at least 20 minutes continuously.

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Head Cancelled

Study tasks performed in head-cancelled conditions

no intervention: Normal

Study tasks performed in normal conditions.

Interventions

Head-cancelled virtual reality

Scene in virtual reality moves with the head while performing visual tasks.

Primary outcome measure

Peak saccade amplitude [ Time Frame: 5 minutes ]

Central Contacts and Locations

Central contacts

Kevin Houston, OD

508-753-5103 khouston@wsvisionsource.com

Shelli Levasseur, BS

5087535103 mlevasseur@wsvisionsource.com

Locations

Brooks Rehabilitation Hospital

Recruiting

Jacksonville, Florida, United States, 32216

Contacts

Hannah Grimes

904-345-7373 Hannah.Grimes@Brooksrehab.org

Katelyn Jordan, OD

904-345-7373 katelyn.jordan@brooksrehab.org

Principal Investigator:

Katelyn Jordan, OD

Vision Source of Worcester

Recruiting

Worcester, Massachusetts, United States, 01610

Contacts

Kevin E Houston, OD

508-753-5103 khouston@wsvisionsource.com

Shelli Levasseur

508-753-5103 mlevasseur@wsvisionsource.com

Principal Investigator:

Kevin E Houston, OD

More Information

Sponsor

Kevin Houston

Last update posted

Apr 6, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Kevin Houston on 2026-04-06.