Recruiting

Observational Study

Sponsor:

St. Jude Children's Research Hospital

Code:

NCT06421987

Conditions

Hodgkin Lymphoma, Adult

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Near Infrared Spectroscopy (NIRS)

Study Details

Brief summary:

SURVIVORS

Study participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. The study is being done to help investigators understand the link between long term effects of chest radiation and bleomycin for HL and brain function in survivors.

Primary Objective To evaluate dynamic changes in CBF and oxygenation during exercise with Near Infrared Spectroscopy (NIRS) in HL survivors and non-cancer controls matched for age, sex, race, and ethnicity. .

Secondary Objectives To examine the degree of CO2 clearance (DLCO/ETCO2) during rest and exercise in Hodgkin Lymphoma (HL) survivors compared to non-cancer controls matched for age, sex, race, and ethnicity.

CONTROLS

Volunteers are being asked to take part in this research study because they are non-first degree relative or friend of someone who received treatment for a childhood cancer or similar illness at St. Jude Children's Research Hospital or are an employee/affiliate of St. Jude Children's Research Hospital and have agreed to be a St. Jude Life Cohort Study (SJLIFE) community control.

Conditions

Hodgkin Lymphoma, Adult

Study ID

NCT06421987

Start date

May 6, 2024

Status verified date

Aug, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

HL Survivors

  • Completed bleomycin and/or thoracic radiation therapy for HL at SJCRH.
  • <21-years old at diagnosis; currently ≥18-years of age and ≥2-years post therapy.
  • SJLIFE or ACT/SJLIFE participants
  • English language proficiency.

Community Controls

  • SJLIFE control.
  • ≥18-years of age at the time of enrollment with age sampling to broadly match the HL survivors.

Exclusion Criteria:

HL Survivors

  • History of cranial or total-body irradiation therapy.
  • History of intrathecal or high dose intravenous antimetabolite therapy.
  • History of head injury or diagnosis of a genetic disorder associated with cognitive impairment.

Study Design

Enrollment

100 participants

Anticipated

Interventions and Outcome Measures

Arms

SURVIVOR

A survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital.

and Control: Voluntarily taking part in this study because you are a relative, friend or employee of St. Jude Children's Research Hospital.

Interventions

Near Infrared Spectroscopy (NIRS)

NIRS is a portable, non-invasive, brain imaging device.

Primary outcome measure

  • Near-Infrared Spectroscopy (NIRS) [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Nicholas Phillips, PhD

888-226-4343referralinfo@stjude.org

Locations

St. Jude Children's Research Hospital

Recruiting

Memphis, Tennessee, United States, 38105

Contacts

Nicholas Phillips, PhD

888-226-4343referralinfo@stjude.org

Principal Investigator:

Nicholas Phillips, PhD

More Information

Sponsor

St. Jude Children's Research Hospital

Last update posted

Sep 1, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by St. Jude Children's Research Hospital on 2026-09-01.