Recruiting

Advanced MRI

Sponsor:

Brigham and Women's Hospital

Code:

NCT06423768

Conditions

Cardiac Arrest

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The goal of this observational study is to determine whether specific advanced MRI measures are associated with functional outcomes in patients who are comatose after cardiac arrest. The main question\[s\] it aims to answer are:

Aim 1: Determine if stimulus-based functional MRI (fMRI)-measured activations are independently associated with favorable neurological outcomes after cardiac arrest

Aim 2: Determine if resting state functional MRI (rs-fMRI)-measured functional network connectivity is independently associated with favorable neurological outcomes after cardiac arrest.

Aim 3: Determine if diffusion tensor imaging (DTI)-measured white matter integrity is associated with favorable neurological outcomes after cardiac arrest.

Participants will undergo advanced MRI sequences at time of clinical MRI, and will be followed for 6 months post-arrest.

Conditions

Cardiac Arrest

Study ID

NCT06423768

Start date

May 16, 2024

Status verified date

Jun, 2026

Completion date

Dec 1, 2027

Anticipated

Primary completion date

Jun 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • survive of an in or out of hospital cardiac arrest

Exclusion Criteria:

  • Drug overdose
  • Opinion of medical team patient unlikely to survive more than 24 hours (severe concurrent medical illness, dilated and unreactive pupils, etc..)
  • Following verbal commands (MD or RN note) once TTM is complete and normothermia is achieved (Day 2 or 3; Day of admission is Hospital Day 0). If no TTM is administered, this can be assessed on Hospital Day 2.
  • Following verbal commands (study team assessment) at time of MRI
  • Family planning to WLST at time of enrollment
  • Non English speaker (okay if English not primary language, as long as they can understand it)
  • Permanent Contraindication to MRI (some kind of implanted metal)
  • Pregnant

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Cerebral Performance Category Score 1-2 [ Time Frame: 6 months ]

Central Contacts and Locations

Central contacts

Samuel B Snider, MD

857-307-2391ssnider@bwh.harvard.edu

Locations

Brigham and Women's Hospital

Recruiting

Brookline, Massachusetts, United States, 02114

Contacts

Sam Snider

9196142137ssnider@partners.org

More Information

Sponsor

Brigham and Women's Hospital

Last update posted

Jun 22, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Brigham and Women's Hospital on 2026-06-22.