Recruiting

Observational StudyA Registry for People With Lung Cancer

Sponsor:

Memorial Sloan Kettering Cancer Center

Code:

NCT06424327

Conditions

Lung Cancer

Lung Cancer Stage I

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Patient-Reported Outcomes Measurement Information System

Study Details

Brief summary:

Participants will complete questionnaires before surgery, between 2 to 4 weeks after surgery, and 6 months after surgery.

Conditions

Lung Cancer

Lung Cancer Stage I

Study ID

NCT06424327

Start date

May 15, 2024

Status verified date

Aug, 2026

Completion date

May 15, 2029

Anticipated

Primary completion date

May 15, 2029

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Age ≥18 years
Patients suitable for segmentectomy, according to the treating surgeon
Clinical Stage I with suspected NSCLC, classified preoperatively based on the AJCC TNM staging manual, 9th edition o Note: Tissue diagnosis of NSCLC is not required before enrollment. A pathologic diagnosis of NSCLC may be confirmed preoperatively with biopsy, intraoperatively with frozen section, or postoperatively on final pathology

Exclusion Criteria:

Actively receiving lung cancer treatment or a history of lung cancer in the previous 5 years
History of chemotherapy or radiation therapy for a previous lung cancer
Synchronous secondary cancer in the lung or elsewhere in the body at the time of surgery
Carcinoid tumors
History of other malignancies within the past 3 years, with the exception of non-melanoma skin cancer, superficial bladder cancer, and carcinoma in situ of the cervix
Actively receiving treatment for other malignancies
Cases of lobectomy in conjunction with segmentectomy from another lobe and ≥2 segmentectomies from different lobes either en bloc or separate will be excluded from the primary analysis.

Multi-segmental resection from the same lobe is not a criterion for exclusion.

Study Design

Enrollment

600 participants

Anticipated

Interventions and Outcome Measures

Arms

Participants with Lung Cancer

Participants undergoing planned pulmonary segmentectomy for primary lung cancer

Interventions

Patient-Reported Outcomes Measurement Information System

Participants-reported outcomes will be collected using the Patient-Reported Outcomes Measurement Information System (PROMIS). PROMIS is a web-based platform developed by the National Institutes of Health. Scoring is standardized on a scale from 0 to 100, with a population mean of 50 and standard deviation of 10 units. High scores mean more of the concept being measured. This study will use PROMIS surveys assessing three domains: physical function (PROMIS bank version 2.0), pain interference (PROMIS bank version 1.1), and dyspnea severity (PROMIS bank version 1.0)

Primary outcome measure

Determine 3-year disease-free survival/DFS among patients undergoing pulmonary segmentectomy for lung cancer. [ Time Frame: 3 years ]
Determine 5-year disease-free survival/DFS among patients undergoing pulmonary segmentectomy for lung cancer. [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

David Jones, MD

212-639-6428 jonesd2@mskcc.org

Bernard Park, MD

646-888-3346 parkb@mskcc.org

Locations

University of Arizona (Data Collection Only)

Recruiting

Tucson, Arizona, United States, 85704

Contacts

Praveen Sridhar, MD

520-694-2873 psridhar@arizona.edu

University of California San Diego (Data collection)

Recruiting

San Diego, California, United States, 92103

Contacts

Joshua Boys, MD

858-657-7777

Rush University Medical Center (Data collection only)

Recruiting

Chicago, Illinois, United States, 606012

Contacts

Christopher Seder, MD

312-738-3732

Endeavor Health

Recruiting

Evanston, Illinois, United States, 60201

Contacts

Seth Krantz, MD

847-570-2868

University of Michigan (Data Collection Only)

Recruiting

Ann Arbor, Michigan, United States, 48109

Contacts

Jules Lin, MD

734-936-8857

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Recruiting

Basking Ridge, New Jersey, United States, 07920

Contacts

David Jones, MD

212-639-6428

Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

Recruiting

Middletown, New Jersey, United States, 07748

Contacts

David Jones, MD

212-639-6428

Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Recruiting

Montvale, New Jersey, United States, 07645

Contacts

David Jones, MD

212-639-6428

Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)

Recruiting

Commack, New York, United States, 11725

Contacts

David Jones, MD

212-639-6428

Memorial Sloan Kettering Westchester (Limited Protocol Activities)

Recruiting

Harrison, New York, United States, 10604

Contacts

David Jones, MD

212-639-6428

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

Recruiting

New York, New York, United States, 10065

Contacts

David Jones, MD

212-639-6428

Yuan Liu, MD, PhD

646-888-3640

Principal Investigator:

David Jones, PhD

Memorial Sloan Kettering Nassau (Limited Protocol Activities)

Recruiting

Uniondale, New York, United States, 11553

Contacts

David Jones, MD

212-639-6428

Thomas Jefferson University Hospital (Data Collection Only)

Recruiting

Philadelphia, Pennsylvania, United States, 19107

Contacts

Nathaniel Evans III, MD

nathaniel.evans@jefferson.edu

ALLEGHENY HEALTH NETWORK (Data Collection Only)

Recruiting

Pittsburgh, Pennsylvania, United States, 15212

Contacts

Benny Weksler, MD

412-359-6137

Baylor University Medical Center (Data Collection Only)

Recruiting

Dallas, Texas, United States, 75246

Contacts

Shanda Blackmon, MD, MPH

713-198-6376 sshanda.blackmon@bcm.edu

MD Anderson Cancer Center (Data Collection Only)

Recruiting

Houston, Texas, United States, 77030

Contacts

David Rice, MD

800-392-1611

University Health Network (Data Collection Only)

Recruiting

Toronto, Ontario, Canada, M5G 2C4

Contacts

Elliot Wakeam, MD

elliot.wakeam@uhn.ca

Centre Hospitalier de l'Université de Montreal (Data Collection Only)

Recruiting

Montreal, Quebec, Canada, H2L 4M1

Contacts

Moishe Liberman, MD. PhD

514-890-8000, ext: 26832

More Information

Sponsor

Memorial Sloan Kettering Cancer Center

Last update posted

Aug 7, 2026

Last verified

Aug, 2026

Keywords

lung cancer
lung cancer stage 1
segmentectomy
Memorial Sloan Kettering Cancer Center
24-127

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center on 2026-08-07.