Recruiting

Observational Study

Sponsor:

McGill University

Code:

NCT06431334

Conditions

Healthy

Increased Metabolic Requirements

Dietary Reference Intakes

Eligibility Criteria

Sex: Male

Age: 65+

Healthy Volunteers: Accepted

Interventions

Amino Acid Intake

Study Details

Brief summary:

Masters level cyclists are a population above the age of 35 years who frequently participate in prolonged as well as heavy-volume training. Like most endurance-trained athletes, a greater recommended dietary allowance (RDA) for protein of 1.2-1.4 g/kg/bw is suggested.

Dietary protein intake is vital for maximizing the benefits of training and ensuring optimal recovery. Dietary recommendations traditionally have been determined through nitrogen balance techniques, however, recent research indicates how this method is potentially underestimating protein requirements. Therefore, there is a need to reassess current dietary recommendations in order to meet the demands of physical activity for highly active populations.

Recent efforts to understand protein requirements during rest and following exercise have been completed using the indicator amino acid technique (IAAO). This non-invasive method is reported to provide a robust measure of protein requirements. However, there is limited work in older (≥60 years) active populations.

The purpose of this study is to measure the protein requirements in master cyclists, following an endurance training session, using the non-invasive IAAO technique.

Conditions

Healthy

Increased Metabolic Requirements

Dietary Reference Intakes

Study ID

NCT06431334

Start date

Jun 21, 2024

Status verified date

Feb, 2026

Completion date

Jun, 2026

Anticipated

Primary completion date

Jun, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Male

Age: 65+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18.5< BMI <35 kg/m\^2
  • Overtly healthy masters level cyclists ≥65 years
  • Masters level cyclist training (>4 days per week; \~100 km per week)
  • Body mass stable over previous 6-months
  • Availability for multiple metabolic trials (\~7 trials)
  • Ability to travel to and from laboratory facility

Exclusion Criteria:

  • Recent history of weight loss or weight gain (>5% body weight)
  • Uncontrolled hypertension
  • ≥2 chronic diseases (e.g. diabetes, osteoporosis, dyslipidemia)
  • Acute illness that could affect protein metabolism (HIV, renal dysfunction, influenza)
  • Currently using anti-inflammatory medications
  • Inability to adhere to study protocol (i.e., alcohol, caffeine, dietary restrictions)
  • Regular tobacco user
  • Illicit drug use
  • Habitually ingesting ≥3 g/kg/bw

Study Design

Enrollment

8 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Masters Level Cyclists

Participants are to be randomly assigned varying levels of amino acid intakes ranging between 0.2 to 2.8 g/kg/d

Interventions

Amino Acid Intake

Amino acid intakes will vary between 0.2 to 2.8 g/kg/d

Primary outcome measure

  • 13CO2 Excretion [ Time Frame: 7-weeks ]

Central Contacts and Locations

Central contacts

Locations

McGill University

Recruiting

Montreal, Quebec, Canada, H3A 0G4

Contacts

Principal Investigator:

Tyler Churchward-Venne, PhD

More Information

Sponsor

McGill University

Last update posted

Feb 9, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by McGill University on 2026-02-09.