Recruiting

BriumviA Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

Sponsor:

TG Therapeutics, Inc.

Code:

NCT06433752

Conditions

Relapsing Multiple Sclerosis

Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

No Intervention

Study Details

Brief summary:

The purpose of this study is to evaluate safety, effiectiveness, and to gain insight into the treatment experience of participants prescribed BRIUMVI® (ublituximab-xiiy) in the real-world setting

Conditions

Relapsing Multiple Sclerosis

Multiple Sclerosis

Study ID

NCT06433752

Start date

Jul 22, 2024

Status verified date

Aug, 2026

Completion date

Apr 1, 2032

Anticipated

Primary completion date

Apr 1, 2032

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Confirmed Multiple Sclerosis (MS) diagnosis.
2. Participants who have not received any BRIUMVI® (ublituximab-xiiy) infusion prior to study start. Participants who have been prescribed BRIUMVI® (ublituximab-xiiy) but have not yet received their first infusion on Day 1 of 150 milligrams (mg) can be included.

Exclusion Criteria:

1. Have received any live or live-attenuated vaccines (including for varicella-zoster virus or measles) within 4 weeks prior to first BRIUMVI® (ublituximab-xiiy) administration or any non-live vaccines within 2 weeks prior to first BRIUMVI® (ublituximab-xiiy) administration.
2. Any active infection (e.g., active Hepatitis B virus \[HBV\])
3. Concurrent participation in any interventional MS trials, or planned concurrent treatment with other Multiple Sclerosis Disease Modifying Therapy (MS DMT) during the study period.

Study Design

Enrollment

2000 participants

Anticipated

Interventions and Outcome Measures

Arms

BRIUMVI® (Ublituximab-xiiy)

Participants will receive BRIUMVI® (Ublituximab-xiiy) intravenous (IV) infusion for the treatment of RMS.

Interventions

No Intervention

No Intervention

Primary outcome measure

Annualized Relapse Rate (ARR) [ Time Frame: Up to Week 96 ]

Central Contacts and Locations

Central contacts

TG Therapeutics Clinical Support Team

1-877-575-8489 clinicalsupport@tgtxinc.com

Locations

TG Therapeutics Investigational Trial Site

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Birmingham, Alabama, United States, 35209

TG Therapeutics Investigational Trial Site

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Cullman, Alabama, United States, 35058

TG Therapeutics Investigational Trial Site

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Huntsville, Alabama, United States, 35802

TG Therapeutics Investigational Trial Site

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Mobile, Alabama, United States, 36604

TG Therapeutics Investigational Trial Site

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Gilbert, Arizona, United States, 85297

TG Therapeutics Investigational Trial Site

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Phoenix, Arizona, United States, 85032

TG Therapeutics Investigational Trial Site

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Scottsdale, Arizona, United States, 85253

TG Therapeutics Investigational Trial Site

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Fresno, California, United States, 93720

TG Therapeutics Investigational Trial Site

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Newport Beach, California, United States, 92663

TG Therapeutics Investigational Trial Site

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Orange, California, United States, 68130

TG Therapeutics Investigational Trial Site

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West Hollywood, California, United States, 90048

TG Therapeutics Investigational Trial Site

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Aurora, Colorado, United States, 80045

TG Therapeutics Investigational Trial Site

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Basalt, Colorado, United States, 81621

TG Therapeutics Investigational Trial Site

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Colorado Springs, Colorado, United States, 80918

TG Therapeutics Investigational Trial Site

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Colorado Springs, Colorado, United States, 80920

TG Therapeutics Investigational Trial Site

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Denver, Colorado, United States, 80222

TG Therapeutics Investigational Trial Site

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Fort Collins, Colorado, United States, 80528

TG Therapeutics Investigational Trial Site

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Grand Junction, Colorado, United States, 81501

TG Therapeutics Investigational Trial Site

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Farmington, Connecticut, United States, 06032

TG Therapeutics Investigational Trial Site

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Hartford, Connecticut, United States, 06112

TG Therapeutics Investigational Trial Site

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Washington D.C., District of Columbia, United States, 20010

TG Therapeutics Investigational Trial Site

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Altamonte Springs, Florida, United States, 32714

TG Therapeutics Investigational Trial Site

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Boca Raton, Florida, United States, 33486

TG Therapeutics Investigational Trial Site

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Clearwater, Florida, United States, 33761

TG Therapeutics Investigational Trial Site

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Gainesville, Florida, United States, 32611

TG Therapeutics Investigational Trial Site

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Maitland, Florida, United States, 32751

TG Therapeutics Investigational Trial Site

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Miami, Florida, United States, 33176

TG Therapeutics Investigational Trial Site

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Naples, Florida, United States, 34105

TG Therapeutics Investigational Trial Site

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Orlando, Florida, United States, 32806

TG Therapeutics Investigational Trial Site

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Pensacola, Florida, United States, 32504

TG Therapeutics Investigational Trial Site

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Weston, Florida, United States, 33331

TG Therapeutics Investigational Trial Site

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Atlanta, Georgia, United States, 30309

TG Therapeutics Investigational Trial Site

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Atlanta, Georgia, United States, 30327

TG Therapeutics Investigational Trial Site

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Savannah, Georgia, United States, 31406

TG Therapeutics Investigational Trial Site

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Smyrna, Georgia, United States, 30080

TG Therapeutics Investigational Trial Site

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Honolulu, Hawaii, United States, 96817

TG Therapeutics Investigational Trial Site

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Coeur d'Alene, Idaho, United States, 83814

TG Therapeutics Investigational Trial Site

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Chicago, Illinois, United States, 60611

TG Therapeutics Investigational Trial Site

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Chicago, Illinois, United States, 60612

TG Therapeutics Investigational Trial Site

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Evanston, Illinois, United States, 60201

TG Therapeutics Investigational Trial Site

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Urbana, Illinois, United States, 61801

TG Therapeutics Investigational Trial Site

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Avon, Indiana, United States, 46123

TG Therapeutics Investigational Trial Site

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Roeland Park, Kansas, United States, 66205

TG Therapeutics Investigational Trial Site

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Lexington, Kentucky, United States, 40504

TG Therapeutics Investigational Trial Site

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Louisville, Kentucky, United States, 40202

TG Therapeutics Investigational Trial Site

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Baltimore, Maryland, United States, 21237

TG Therapeutics Investigational Trial Site

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Glen Burnie, Maryland, United States, 21061

TG Therapeutics Investigational Trial Site

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Boston, Massachusetts, United States, 02215

TG Therapeutics Investigational Trial Site

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Burlington, Massachusetts, United States, 01805

TG Therapeutics Investigational Trial Site

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Norfolk, Massachusetts, United States, 02481

TG Therapeutics Investigational Trial Site

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Ann Arbor, Michigan, United States, 48019

TG Therapeutics Investigational Trial Site

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Detroit, Michigan, United States, 48202

TG Therapeutics Investigational Trial Site

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Farmington, Michigan, United States, 48334

TG Therapeutics Investigational Trial Site

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Owosso, Michigan, United States, 48867

TG Therapeutics Investigational Trial Site

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Rochester Hills, Michigan, United States, 48307

TG Therapeutics Investigational Trial Site

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Golden Valley, Minnesota, United States, 55422

TG Therapeutics Investigational Trial Site

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Plymouth, Minnesota, United States, 55446

TG Therapeutics Investigational Trial Site

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Billings, Montana, United States, 59101

TG Therapeutics Investigational Trial Site

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Omaha, Nebraska, United States, 68154

TG Therapeutics Investigational Trial Site

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Las Vegas, Nevada, United States, 89106

TG Therapeutics Investigational Trial Site

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Bridgewater, New Jersey, United States, 08807

TG Therapeutics Investigational Trial Site

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Cherry Hill, New Jersey, United States, 08002

TG Therapeutics Investigational Trial Site

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Freehold, New Jersey, United States, 07728

TG Therapeutics Investigational Trial Site

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Livingston, New Jersey, United States, 07039

TG Therapeutics Investigational Trial Site

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Neptune City, New Jersey, United States, 00753

TG Therapeutics Investigational Trial Site

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Teaneck, New Jersey, United States, 07666

TG Therapeutics Investigational Trial Site

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Amherst, New York, United States, 14226

TG Therapeutics Investigational Trial Site

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New York, New York, United States, 11501

TG Therapeutics Investigational Trial Site

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Charlotte, North Carolina, United States, 28210

TG Therapeutics Investigational Trial Site

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New Bern, North Carolina, United States, 28562

TG Therapeutics Investigational Trial Site

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Raleigh, North Carolina, United States, 27607

TG Therapeutics Investigational Trial Site

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Centerville, Ohio, United States, 45429

TG Therapeutics Investigational Trial Site

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Centerville, Ohio, United States, 45459

TG Therapeutics Investigational Trial Site

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Cincinnati, Ohio, United States, 45212

TG Therapeutics Investigational Trial Site

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Cleveland, Ohio, United States, 44195

TG Therapeutics Investigational Trial Site

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Columbus, Ohio, United States, 43214

TG Therapeutics Investigational Trial Site

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Columbus, Ohio, United States, 43235

TG Therapeutics Investigational Trial Site

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Toledo, Ohio, United States, 43608

TG Therapeutics Investigational Trial Site

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Norman, Oklahoma, United States, 73019

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Portland, Oregon, United States, 97225

TG Therapeutics Investigational Trial Site

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Bethlehem, Pennsylvania, United States, 18017

TG Therapeutics Investigational Trial Site

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Franklin, Tennessee, United States, 37067

TG Therapeutics Investigational Trial Site

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Knoxville, Tennessee, United States, 37996

TG Therapeutics Investigational Trial Site

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Mount Juliet, Tennessee, United States, 37122

TG Therapeutics Investigational Trial Site

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Nashville, Tennessee, United States, 37215

TG Therapeutics Investigational Trial Site

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Spring Hill, Tennessee, United States, 37174

TG Therapeutics Investigational Trial Site

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Austin, Texas, United States, 78712

TG Therapeutics Investigational Trial Site

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Austin, Texas, United States, 78723

TG Therapeutics Investigational Trial Site

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Austin, Texas, United States, 78758

TG Therapeutics Investigational Trial Site

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Dallas, Texas, United States, 75206

TG Therapeutics Investigational Trial Site

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Dallas, Texas, United States, 75243

TG Therapeutics Investigational Trial Site

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Edinburg, Texas, United States, 78572

TG Therapeutics Investigational Trial Site

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Frisco, Texas, United States, 75035

TG Therapeutics Investigational Trial Site

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Lubbock, Texas, United States, 79414

TG Therapeutics Investigational Trial Site

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San Antonio, Texas, United States, 78229

TG Therapeutics Investigational Trial Site

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Ogden, Utah, United States, 84403

TG Therapeutics Investigational Trial Site

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Salt Lake City, Utah, United States, 84103

TG Therapeutics Investigational Trial Site

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Smith, Utah, United States, 84148

TG Therapeutics Investigational Trial Site

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Charlottesville, Virginia, United States, 22908

TG Therapeutics Investigational Trial Site

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Salem, Virginia, United States, 24153

TG Therapeutics Investigational Trial Site

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Vienna, Virginia, United States, 22182

TG Therapeutics Investigational Trial Site

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Virginia Beach, Virginia, United States, 23456

TG Therapeutics Investigational Trial Site

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Kirkland, Washington, United States, 98034

TG Therapeutics Investigational Trial Site

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Morgantown, West Virginia, United States, 26506

TG Therapeutics Investigational Trial Site

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Greenfield, Wisconsin, United States, 53228

TG Therapeutics Investigational Trial Site

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Milwaukee, Wisconsin, United States, 53226

TG Therapeutics Investigational Trial Site

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Neenah, Wisconsin, United States, 54956

TG Therapeutics Investigational Trial Site

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Waukesha, Wisconsin, United States, 53188

More Information

Sponsor

TG Therapeutics, Inc.

Last update posted

Aug 31, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by TG Therapeutics, Inc. on 2026-08-31.