Recruiting

Blood Flow Restriction

Sponsor:

Medical College of Wisconsin

Code:

NCT06441422

Conditions

Weakness, Muscle

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Blood flow restriction training

No blood flow restriction training

Study Details

Brief summary:

A large portion of the American population live with disabilities. People with disabilities can find it difficult to perform standard exercise routines. Regular exercise is necessary to be healthy, especially as people age. Lack of exercise can lead to secondary health concerns, like loss of muscle mass, diabetes, heart attack or stroke, to name a few. For exercise to be most beneficial, a certain degree of intensity must be achieved. Low load blood flow restriction training may be able to mimic the intensity of beneficial exercise without actually exercising hard. It may be a good option for people with disabilities who find it difficult to exercise.

Conditions

Weakness, Muscle

Study ID

NCT06441422

Start date

Dec 12, 2024

Status verified date

Apr, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Male or female
  • Age > or = 18
  • English speaking
  • Able to understand and perform upper extremity exercises

Exclusion Criteria:

  • Pregnant
  • Body mass index >40 kg·m-2
  • Uncontrolled hypertension (>150/90 mmHg)
  • Presence of neuromuscular junction and other muscle diseases
  • Myocardial infarction in the past 6 months
  • Unstable cardiovascular disease
  • History of an upper limb deep vein thrombosis
  • History of autonomic dysreflexia
  • Upper extremity fracture within the last 6 months

Study Design

Enrollment

24 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Low load resistance training with blood flow restriction

Low load resistance training routine at 30-50% of a person's 1-repetition maximum with arterial occlusion pressure at 80%

active comparator: Low load resistance training

Low load resistance training routine at 30-50% of a person's 1-repetition maximum

Interventions

Blood flow restriction training

Participants randomized to blood flow restriction training will complete low load resistance training exercises while the limb is occluded at 80% arterial occlusion pressure.

No blood flow restriction training

Participants randomized to no blood flow restriction training will complete low load resistance without occlusion.

Primary outcome measure

  • Difference in strength between low load blood flow restriction resistance training and low load resistance training [ Time Frame: 6 weeks ]
  • Difference in arm circumference between low load blood flow restriction resistance training and low load resistance training [ Time Frame: 6 weeks ]
  • Difference in muscle thickness change between low load blood flow restriction resistance training and low load resistance training [ Time Frame: 6 weeks ]

Central Contacts and Locations

Central contacts

Beth Weinman, DO

414-955-1922bweinman@mcw.edu

Meghann Sytsma

414-955-1922mesytsma@mcw.edu

Locations

Medical College of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Beth Weinman, DO

414-805-7100bweinman@mcw.edu

More Information

Sponsor

Medical College of Wisconsin

Last update posted

May 1, 2026

Last verified

Apr, 2026

Keywords

  • Disability
  • Blood flow restriction
  • Low load blood flow restriction training

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Medical College of Wisconsin on 2026-05-01.