Recruiting

Extubation Complications

Sponsor:

University Health Network, Toronto

Code:

NCT06442930

Conditions

Extubation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

EXTUBE is an international, multicentre, prospective cohort study evaluating the incidence, risk factors, and outcomes of extubation-related complications and describing clinical practices related to extubation after general anesthesia or after critical illness in the operating room (OR), out of OR anesthesia location or intensive care unit (ICU).

Conditions

Extubation

Study ID

NCT06442930

Start date

Apr 14, 2025

Status verified date

Aug, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult patients (≥18 years old)
  • Undergoing extubation of an endotracheal tube (including index extubation and re-extubations) after general anesthesia in the OR, out of OR anesthesia location or ICU
  • Undergoing extubation during the specified enrollment window

Exclusion Criteria:

  • Patients will be excluded if the extubation is performed in the context of withdrawal of life support measures,
  • Patients will be excluded if the extubation is performed for tracheostomy decannulation

For each patient who is not included, reasons for exclusion will be reported.

Study Design

Enrollment

3000 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • At least one of the following, occurring within 60minutes after extubation (composite outcome): i) Severe hypoxemia ii) Cardiac arrest iii) Need for airway management [ Time Frame: Within 60 minutes after the end of extubation ]

Central Contacts and Locations

Central contacts

Matteo Parotto, MD, PhD

+1 416 340 3567matteo.parotto@uhn.ca

Shayan Wasim, MPH, BSc

+1 416 340 4800shayan.wasim@uhn.ca

Locations

University Health Network - Toronto General Hospital

Recruiting

Toronto, Ontario, Canada, M5G 2C4

Contacts

Matteo Parotto, MD, PhD

416-340-3567matteo.parotto@uhn.ca

Shayan Wasim, MPH, BSc

416-340-4800shayan.wasim@uhn.ca

Principal Investigator:

Matteo Parotto, MD, PhD

More Information

Sponsor

University Health Network, Toronto

Last update posted

Sep 8, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University Health Network, Toronto on 2026-09-08.