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Immersive Virtual Reality

Sponsor:

Case Comprehensive Cancer Center

Code:

NCT06446115

Conditions

Malignant Neoplasm

Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Virtual Reality

Preferred activity

Questionnaires

Study Details

Brief summary:

The goal of this clinical trial is to learn if the use of virtual reality during chemotherapy treatment helps participants achieve an improvement in distress, which may include unpleasant experience, anxiety, depression and/or pain.

Participants will:

  • Be randomly assigned to one of two available groups (virtual reality or standard of care)
  • Participations will only be during one chemotherapy session.
  • Those assigned to virtual reality:

  • The research team will provide a virtual reality
  • The research team will provide guidance on how the headset works and will be available to assist with any questions or concerns.
  • Participants will also be able to choose different relaxing backgrounds depending on their preference. headset during the chemotherapy session for 15 to 30 minutes
  • Those assigned to the standard of care:

  • The research team will provide the participants with the opportunity to choose a preferred activity such as reading a book, watching television, etc.

Conditions

Malignant Neoplasm

Cancer

Study ID

NCT06446115

Start date

Nov 5, 2024

Status verified date

Apr, 2026

Completion date

Apr 30, 2025

Primary completion date

Apr 30, 2025

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥ 18 years.
  • Biopsy proven diagnosis of Cancer (any stage or type).
  • Must have a National Comprehensive Cancer Network Distress Thermometer Score ≥ 5 any time since diagnosis.
  • Must have the ability to understand and the willingness to sign a written informed consent document
  • Followed by a medical oncologist, radiation oncologist, and/or breast surgeon at Cleveland Clinic.
  • Ability to read and write in English or Spanish.

Exclusion Criteria:

  • Age <18 years.
  • No prior history of Cancer.
  • Prior medical history of severe motion sickness.
  • Prior medical history of seizures
  • Pregnancy.
  • Unable or unwilling to participate in the immersive Virtual Reality study at the Maroone Cancer Center

Study Design

Enrollment

68 participants

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Virtual reality

Participants will be asked to use a headset device during 15 to 30 minutes while receiving a chemotherapy infusion. Participants have the option to choose from different virtual reality setting depending on their preference (i.e., nature videos, meditations, interactive applications, among others).

active comparator: Standard of care

Participants will be asked to choose any activity of your preference during the chemotherapy session (i.e., watching tv, reading a book, listening to music or a podcast, etc.)

Interventions

Virtual Reality

Virtual Reality Headset applied to the participants during chemotherapy session. Participants select their preferred virtual reality experience (i.e., nature videos, meditations, interactive applications, etc). Virtual reality (VR) by definition, is a simulated experience consisting of an experiential environment created by hardware and software technology capable of provoking sensations of real experiences. It can be further divided into 1) immersive; 2) semi-immersive; and 3) non-immersive. Immersive VR employs head-mounted display (HMD) system technology to separate users from their surroundings and engage in real-time with a three-dimensional environment generated by a computer.

Preferred activity

Participants will engage in a preferred activity such as reading, watching television, coloring, etc. during chemotherapy.

Questionnaires

Participants will be administered multiple pre and post intervention questionnaires including NCCN Distress thermometer, GAD-7 and CCVA.

Primary outcome measure

  • Change in distress scores between pre- and post-intervention [ Time Frame: Pre-intervention window of +/- 1 hours before intervention; post-intervention window of +/-1 hours post intervention ]

Central Contacts and Locations

More Information

Sponsor

Case Comprehensive Cancer Center

Last update posted

Apr 29, 2026

Last verified

Apr, 2026

Keywords

  • Virtual Reality
  • Chemotherapy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-02. This information was provided to ClinicalTrials.gov by Case Comprehensive Cancer Center on 2026-04-29. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.