Recruiting

MIND Diet

Sponsor:

University of Illinois at Urbana-Champaign

Code:

NCT06450977

Conditions

Multiple Sclerosis

Cognitive Change

Nutrition, Healthy

Eligibility Criteria

Sex: All

Age: 18 - 64

Healthy Volunteers: Not accepted

Interventions

MIND Diet

Control Diet

Study Details

Brief summary:

The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in persons with Multiple Sclerosis (MS). The main question it aims to answer is:

Does the MIND diet improve cognitive performance relative to a control diet in persons with MS?

Participants will:

Consume one meal that follows the MIND diet or a control meal every day for 3 months, complete online surveys and cognitive testing before and after, and keep a record of the food they eat during the study.

Conditions

Multiple Sclerosis

Cognitive Change

Nutrition, Healthy

Study ID

NCT06450977

Start date

Jun 7, 2024

Status verified date

Jun, 2024

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Jan 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 64

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Individuals aged 18-64 years old
2. Self-reported diagnosis of Multiple sclerosis (MS)
3. 20/20 or corrected vision
4. No other neurodegenerative disease diagnosis
5. Stable disease-modifying therapy (DMT) within 6 months
6. Not Pregnant or lactating
7. No food allergies or intolerances
8. Able to consume study meals
9. Not enrolled in another dietary, exercise, or medication study during the study
10. Access to a computer/laptop with internet

Exclusion Criteria:

1. Individuals younger than 18 or older than 64 years old
2. No self-reported diagnosis of Multiple sclerosis (MS)
3. Not 20/20 or uncorrected vision
4. Other neurodegenerative disease diagnosis
5. Disease modifying therapy (DMT) less than 6 months
6. Pregnant or lactating
7. Food allergies or intolerances
8. Not able to consume study meals
9. Enrolled in another dietary, exercise, or medication study during the study
10. No access to a computer/laptop with internet

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: MIND Diet

Participants in the active MIND diet group will be asked to consume one ready-to-eat meal per day from Daily Harvest® meal delivery service. The treatment meals will follow MIND diet guidelines and include leafy green vegetables, nuts, legumes, whole grains, berries, and extra virgin olive oil.

active comparator: Control Diet

Participants in the control diet group will be asked to consume one ready-to-eat meal per day from Daily Harvest® meal delivery service. The Control group will receive daily meals that are isocaloric with the active/experimental meals but will follow a general diet based on the average American diet and Dietary Guidelines for Americans (i.e., vegetables, fruits, nuts, whole grains, and unsaturated fats).

Interventions

MIND Diet

Daily meals designed to increase adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) dietary pattern.

Control Diet

Daily meals designed to increase fruit, vegetable, and whole grain intake consistent with a healthy American diet.

Primary outcome measure

  • Information Processing [ Time Frame: 12 weeks (Baseline vs. Follow Up) ]
  • Visual Processing [ Time Frame: 12 weeks (Baseline vs. Follow Up) ]
  • Processing Speed [ Time Frame: 12 weeks (Baseline vs. Follow Up) ]
  • Learning [ Time Frame: 12 weeks (Baseline vs. Follow Up) ]
  • Memory [ Time Frame: 12 weeks (Baseline vs. Follow Up) ]
  • MIND Scores [ Time Frame: 12 weeks (Baseline vs. Follow Up) ]

Central Contacts and Locations

Central contacts

Naiman Khan, PhD

2173001667nakhan2@illinois.edu

Locations

University of Illinois Urbana-Champaign

Recruiting

Urbana, Illinois, United States, 61801

More Information

Sponsor

University of Illinois at Urbana-Champaign

Last update posted

Jun 27, 2024

Last verified

Jun, 2024

Keywords

  • Executive Function
  • MIND
  • Dietary Pattern
  • Telehealth

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Illinois at Urbana-Champaign on 2024-06-27.