Home Dialysis & In-Center HemodialysisQuality of Life in Patients Transitioning to Home or In-Center Dialysis (QUALIFY CKD-to-HOME)

The goal of this study is to evaluate quality of life (QoL) and frailty trajectories from advanced chronic kidney disease (CKD) to after dialysis initiation, specifically comparing patients choosing home dialysis and in-center hemodialysis.

The main questions it aims to answer are:

1. What is the trajectory of QoL in patients transitioning from advanced CKD to dialysis (up to 12 months after initiation) and how does these changes differ for patients oriented towards home dialysis and in-center hemodialysis?
2. Is the development of frailty after dialysis initiation less likely in patient pursuing home dialysis?
3. What is the variation in other PROMs and health outcomes (fatigue, anxiety \& depression, general assessment, cognitive function) form advanced CKD to the first 12 months after dialysis initiation?
4. What are the predictors of severe decline in QoL, frailty and other important health outcomes (fatigue, cognition, anxiety \& depression) during CKD G5 follow-up and after 12 months post dialysis initiation?

Participants will be ask to:

• Answer some questions and complete questionnaires each 3 months;
• Do a a grip test and a walking test each 6 months to evaluate their frailty;