Recruiting

Observational Study

Sponsor:

Marquette University

Code:

NCT06465979

Conditions

Hearing

Hearing Loss

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Interventions

Speech Manipulation

Study Details

Brief summary:

Recognition of speech sounds is accomplished through the use of adjacent sounds in time, in what is termed acoustic context. The frequency and temporal properties of these contextual sounds play a large role in recognition of human speech. Historically, most research on both speech perception and sound perception in general examine sounds out-of-context, or presented individually. Further, these studies have been conducted independently of each other with little connection across labs, across sounds, etc. These approaches slow the progress in understanding how listeners with hearing difficulties use context to recognize speech and how their hearing aids and/or cochlear implants might be modified to improve their perception. This research has three main goals. First, the investigators predict that performance in speech sound recognition experiments will be related when testing the same speech frequencies or the same moments in time, but that performance will not be related in further comparisons across speech frequencies or at different moments in time. Second, the investigators predict that adding background noise will make this contextual speech perception more difficult, and that these difficulties will be more severe for listeners with hearing loss. Third, the investigators predict that cochlear implant users will also use surrounding sounds in their speech recognition, but with key differences than healthy-hearing listeners owing to the sound processing done by their implants. In tandem with these goals, the investigators will use computer models to simulate how neurons respond to speech sounds individually and when surrounded by other sounds.

Conditions

Hearing

Hearing Loss

Study ID

NCT06465979

Start date

Sep 19, 2023

Status verified date

Jun, 2026

Completion date

Jul 31, 2028

Anticipated

Primary completion date

Jun 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Be able to recognize spoken words in English
  • Be a competent speaker of north American English
  • Be an adult between the age of 18 to 65 years
  • Have normal audiometric thresholds below 25 decibels hearing loss (dB HL) at frequencies between 250 and 8000 Hz OR have audiometric thresholds not exceeding 40 dB HL at frequencies between 250 and 8000 Hz OR have audiometric thresholds not exceeding 55 dB HL at frequencies between 250 and 8000 Hz OR use a cochlear implant
  • Lack language-learning or other cognitive disabilities

Exclusion Criteria:

  • Inability to recognize spoken words in English
  • Not a competent speaker of north American English
  • Be younger than 18 years of age
  • Be older than 65 years of age
  • Have normal audiometric thresholds exceeding 25 dB HL at frequencies between 250 and 8000 Hz OR have audiometric thresholds exceeding 40 dB HL at frequencies between 250 and 8000 Hz OR have audiometric thresholds exceeding 55 dB HL at frequencies between 250 and 8000 Hz
  • Language-learning or other cognitive disabilities

Study Design

Enrollment

680 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Speech perception experiments

This arm involves experiments wherein participants listen to speech played at comfortable volumes and respond by indicating what they heard either in open-ended form or by choosing among a set of options displayed on a computer.

Interventions

Speech Manipulation

The acoustic properties of speech sounds will be modified in two main ways. The first way is to introduce gradual changes to the perceived articulation of the target speech sound, such as changing from "sh" to "s" by various types of signal processing and filtering. The second type of change is to modify acoustic properties of the sounds that immediately precede the target speech sound, such as changing the speaking rate or its frequencies composition.

Primary outcome measure

  • Speech categorization [ Time Frame: "Post-treatment" where "treatment" is the systematic manipulation of speech sounds. Speech categorization will be evaluated during the main part of the testing. Outcomes will be assessed and data reported through study completion, an average of 1 year ]

Central Contacts and Locations

Central contacts

Locations

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

Marquette University

Recruiting

Milwaukee, Wisconsin, United States, 53233

Contacts

More Information

Sponsor

Marquette University

Last update posted

Jun 3, 2026

Last verified

Jun, 2026

Keywords

  • speech perception
  • hearing

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-25. This information was provided to ClinicalTrials.gov by Marquette University on 2026-06-03. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.