Recruiting

Acute Pain Phenotype

Sponsor:

Brigham and Women's Hospital

Code:

NCT06466941

Conditions

Acute Pain

Chronic Post Operative Pain

Opioid Use

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

regional anesthesia

no regional anesthesia

acute pain consultation

no acute pain consultation

Study Details

Brief summary:

The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and anxiety, who are having surgery.

The main questions are:

1. Do psychosocial factors such as concerns about pain, sleep, anxiety affect the effectiveness of regional anesthesia?
2. Do psychosocial factors and regional anesthesia affect the amount of opioids used after surgery?
3. Do psychosocial factors and regional anesthesia affect development of chronic postsurgical pain?

Conditions

Acute Pain

Chronic Post Operative Pain

Opioid Use

Study ID

NCT06466941

Start date

Jul 3, 2024

Status verified date

May, 2026

Completion date

Dec 31, 2028

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥ 18
  • English speaking
  • Surgical or procedural patient who will be admitted postoperatively
  • Willingness to answer psychosocial survey and/or audio recorded semi-structured interview

Exclusion Criteria:

-Cognitive dysfunction that precludes communication

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

Thoracic surgery and open abdominal surgery

Patients who underwent surgery thoracic surgery or open abdominal surgery

Orthopedic surgery

Patients who underwent orthopedic surgery

Spine surgery

Patients who underwent spine surgery

Interventions

regional anesthesia

Patients who underwent surgery and received an epidural or peripheral nerve block

no regional anesthesia

Patients who underwent surgery and did not received an epidural or peripheral nerve block

acute pain consultation

Patients who underwent surgery and had a perioperative (preop, intraop, or postop) acute pain consultation

no acute pain consultation

Patients who underwent surgery and did not have a perioperative (preop, intraop, or postop) acute pain consultation

Primary outcome measure

  • Maximum pain score over the first 24 hours after surgery [ Time Frame: 0-24 hours ]

Central Contacts and Locations

Central contacts

Yun-Yun K Chen, MD

617-651-0932ykchen@mgb.org

Locations

Brigham and Women's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Yun-Yun Chen, MD

(617) 798-0290‬ykchen@mgb.org

More Information

Sponsor

Brigham and Women's Hospital

Last update posted

May 22, 2026

Last verified

May, 2026

Keywords

  • regional anesthesia
  • peripheral nerve blocks
  • psychosocial phenotype
  • pain catastrophizing

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Brigham and Women's Hospital on 2026-05-22.