Recruiting

Two Photon Microscopy

Sponsor:

University of Rochester

Code:

NCT06473103

Conditions

Basal Cell Carcinoma

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Two photon fluorescence microscopy imaging

Study Details

Brief summary:

The goal of this clinical trial is to compare the use of two photon fluorescence microscopy for detecting residual basal cell carcinoma during standard local excision.

Conditions

Basal Cell Carcinoma

Study ID

NCT06473103

Start date

Oct 29, 2024

Status verified date

Mar, 2025

Completion date

Apr, 2026

Anticipated

Primary completion date

Mar, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Undergoing treatment for basal cell carcinoma without Mohs surgery at the performance site
  • Able to read and understand consent form

Exclusion Criteria:

  • None

Study Design

Enrollment

52 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: TPFM imaging of surgical margins

Excised tissue will be imaged with TPFM to determine the distance from tumor to nearest inked margin.

Interventions

Two photon fluorescence microscopy imaging

Excised tissues will be imaged with two photon fluorescence microscopy prior to submission for histological processing.

Primary outcome measure

  • Quantitative agreement between clear margin distance on TPFM and conventional paraffin embedded histology [ Time Frame: Upon receipt of postoperative pathology slides, typically 2-4 weeks post surgery ]

Central Contacts and Locations

Central contacts

Michael Giacomelli, Ph.D.

5852766260mgiacome@ur.rochester.edu

Locations

Rochester Dermatologic Surgery

Recruiting

Victor, New York, United States, 14654

Contacts

Sherrif Ibrahim, MD-Ph.D.

585-222-1400dr.ibrahim@rochesterdermsurgery.com

More Information

Sponsor

University of Rochester

Last update posted

Mar 17, 2025

Last verified

Mar, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Rochester on 2025-03-17.