Recruiting
Phase 2

Nutrient Timing

Sponsor:

University of Maryland, Baltimore

Code:

NCT06482515

Conditions

Neoplasms

Blood Cancer

Fatigue

Diet Habit

Survivorship

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Time-restricted eating

Nutrition counseling

Study Details

Brief summary:

Cancer-related fatigue affects at least 30-90% of patients with cancer, depending on the type of cancer and their treatment(s) (e.g., chemotherapy, radiation). It is not relieved by sleep or rest, and it sometimes can persist for years after a person's cancer was treated. The fatigue can be so bad that people cannot return to work, hobbies, family roles, or other daily activities, thereby greatly reducing quality of life. The causes of this fatigue are unknown, and we currently do not have anything that can reliably prevent or cure the fatigue. However, there are recent data suggesting that circadian rhythm, or a person's internal body clock, may be disrupted by the cancer experience and contribute to fatigue. Food intake is an external cue that can entrain circadian rhythm. We recently showed that cancer survivors are willing and able to eat all their food within a 10-hour eating window-a practice called time-restricted eating. Herein, we are testing time-restricted eating against a control group (matched for time-, attention, and expectancy) to see if time-restricted eating can indeed alleviate cancer-related fatigue. All participants will be asked to use the myCircadianClock smartphone app to log their food intake and weekly body weight measurements. The participants assigned to the time-restricted eating group will be asked to eat all their food in a 10-hour window during the day. People can choose their start time based on their schedule and preferences, but we ask that the window is the same for the whole study (e.g., 7am-5pm,9:30am-7:30pm). Black coffee and unsweetened tea are allowed before the eating window, and water and medicines are allowed at all times. The participants in the control group will meet with a nutritionist to discuss the American Cancer Society nutrition guidelines in cancer survivorship; they will not be restricted to when they can eat. Participants in both groups will give us valuable information regarding how diet is related to the experience of fatigue. The purpose of this study is to test the effects of a 12-week TRE intervention vs. an unrestricted eating pattern on fatigue, the sustainability of the program at 24 weeks, and the effects of TRE on circadian rhythm and sugar metabolism.

Conditions

Neoplasms

Blood Cancer

Fatigue

Diet Habit

Survivorship

Study ID

NCT06482515

Start date

Nov 4, 2024

Status verified date

Jun, 2026

Completion date

Aug 31, 2028

Anticipated

Primary completion date

May 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion criteria (Participants must…):

  • Have a diagnosis of a hematologic neoplasm (e.g., leukemia, lymphoma, multiple myeloma);
  • Be at least 2 months post-treatment with chemotherapy, radiation, targeted therapy, chimeric antigen receptor (CAR)-T cell therapy, stem cell transplant, or another therapy (maintenance therapies are okay; steady unchanged treatment for relapsed disease for >2 months and expected to stay on it until progression is okay);
  • Have a baseline level of fatigue, as determined by at least one of the following:

1. Reporting a score of 4 or higher in response to the question, "What was your worst fatigue in the last week, on a scale of 0-10, where 0 is no fatigue and 10 is the worst fatigue?"
2. In the habit of taking daytime naps,
3. Have fatigue that interferes with their ability to work, engage in social events, or is more than would be expected from physical exertion,
  • Be able to speak and/or read and write in English or Spanish;
  • Be at least 18 years old; and
  • Be able to provide informed consent.

Exclusion criteria (participants must not…)

  • Be underweight, as defined as a body mass index <18.5 kg/m2;
  • Already eat all their food within a window that is 10 h or shorter most (6/7) days of the week;
  • Be employed in a job where they regularly work away from the home at night (e.g., night shift);
  • Have surgery planned during the study duration;
  • Have any contraindications to the proposed nutrition intervention as identified by their medical provider, their designee, or the study team (e.g., type 1 diabetes, risk for hypoglycemia, medication requirements, pregnancy, breastfeeding, recent history of an eating disorder);
  • Be taking insulin; or
  • Be on enteral or parenteral nutrition.

Study Design

Enrollment

96 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Time-restricted eating

active comparator: Time-unrestricted eating

Interventions

Time-restricted eating

Participants will be asked to eat all their food in a self-selected 10-hour eating window every day.

Nutrition counseling

Participants will meet with a nutritionist to discuss their dietary habits and how they compare to the American Cancer Society nutrition guidelines.

Primary outcome measure

  • Fatigue [ Time Frame: baseline, 6 weeks, 12 weeks ]

Central Contacts and Locations

Central contacts

Amber Kleckner

4107065961amber.kleckner@umaryland.edu

Locations

University of Maryland, Baltimore

Recruiting

Baltimore, Maryland, United States, 21201

Contacts

Amber Kleckner, PhD

4107065961amber.kleckner@umaryland.edu

More Information

Sponsor

University of Maryland, Baltimore

Last update posted

Jun 5, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Maryland, Baltimore on 2026-06-05.