Recruiting

Fractionated Laser Resurfacing

Sponsor:

Wright State University

Code:

NCT06489301

Conditions

Skin Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Fractionated Laser Resurfacing

Study Details

Brief summary:

It has shown that laser wounding of geriatric skin protects it against skin cancer. The purpose of this study is to determine the origin of cells called fibroblasts which are present after treatment with Fractionated Laser Resurfacing (FLR). These cells restore a youth-like ultraviolet B (UVB) response, but where they come from is currently unknown. The study recruits subjects who are scheduled to undergo abdominoplasties to investigate the origin of those cells stimulated by laser treatment.

Conditions

Skin Cancer

Study ID

NCT06489301

Start date

Jul 16, 2025

Status verified date

May, 2026

Completion date

Dec, 2028

Anticipated

Primary completion date

Dec, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult males and females 18 and older
  • Able to comprehend procedures and risks
  • Planning to undergo abdominoplasty surgery
  • Minimum amount of skin to be removed is 50 x 20cm

Exclusion Criteria:

  • Medical history of not well-controlled diabetes. This is defined as a subject who needs high doses of insulin, recent history of hospitalization for diabetes-related complications, or poor wound health as evidenced by diabetic ulcers. Subjects who have been deemed healthy enough for abdominoplasty surgery would tend to suggest that their diabetes should not be an issue. However, if the subjects have diabetic complications as outlined above, they could affect the wound healing which is the object of this protocol so they would be excluded.
  • Pregnant or nursing
  • History of pathologically abnormal wound healing such as keloidal scars
  • Existing tattoos on the abdomen that are so extensive that they could interfere with the study

Study Design

Enrollment

12 participants

Anticipated

Intervention Model

Single group

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Fractionated Laser Resurfacing

At 14 days prior to scheduled surgery a 5x5cm square on the left abdomen within the region of skin to be excised and treated with fractionated laser resurfacing. Then at 7 days prior to scheduled surgery a 5 cm diameter circle on the right abdomen within the region of skin to be excised, at least 10 cm away from the square, is treated with fractionated laser resurfacing.

Interventions

Fractionated Laser Resurfacing

A rejuvenating laser that makes tiny holes in the very superficial part of the skin.

Primary outcome measure

  • To test if the new fibroblasts that develop in response to fractionated laser resurfacing (FLR) wounding are derived from blood-derived monocytes. [ Time Frame: 2 weeks prior to skin removal and 1 week prior to skin removal ]
  • To test if possible cells transitioning from monocytes to fibroblasts are found in the top part of the dermis (papillary dermis). [ Time Frame: 2 weeks prior to skin removal and 1 week prior to skin removal ]

Central Contacts and Locations

Central contacts

Manager, Clinical Research Operations

937-245-7500pturesearch@wrightstatephysicians.org

Regulatory Specialist

937-245-7500pturesearch@wrightstatephysicians.org

Locations

Pharmacology Translational Unit

Recruiting

Fairborn, Ohio, United States, 45324

Contacts

Pharmacology Translational Unit

937-245-7500pturesearch@wrightstatephysicians.org

More Information

Sponsor

Wright State University

Last update posted

May 22, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Wright State University on 2026-05-22.