Recruiting

Light vs. Moderate Intensity Exercise

Sponsor:

HealthPartners Institute

Code:

NCT06491238

Conditions

Myasthenia Gravis

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Light Intensity Exercise

Moderate Intensity Exercise

Study Details

Brief summary:

The overall purpose of this pilot study is to examine the feasibility, acceptability, and tolerability of light and moderate intensity exercise in adults with MGeffect of light vs. moderate intensity exercise on health outcomes. Participants will be enrolled into the NeuroWell exercise program, which is geared toward individuals with neurological disorders or injuries and led by Certified Exercise Physiologists (CEPs) at the HealthPartners Neuroscience Center. A total of 20 people with MG will be enrolled in this study and participate in a small group exercise program 3 times a week for 12 weeks. Participants will be randomized into two exercise groups: 1) Light intensity or 2) Moderate intensity. We hypothesize that light and moderate intensity exercise will be feasible, acceptable, and tolerable in adults with MG and that individuals in the light intensity exercise group will be able to achieve the same improvement in health outcomes as the moderate intensity group.

Conditions

Myasthenia Gravis

Study ID

NCT06491238

Start date

Sep 16, 2024

Status verified date

Mar, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Ability to provide and provision of signed and dated informed consent form.
  • Age 18-80
  • Diagnosis of generalized MG.
  • On a stable MG prescription medication regimen for the last 3 months.

Exclusion Criteria:

  • Non-English speaking
  • Regular exercise participation within the month prior to study enrollment or any outside exercise participation during the study intervention period.
  • Significant cognitive impairment of any etiology that would impact study participation.
  • History of heart failure, chronic lung disease, angina or any other condition that causes unreasonable shortness of breath on exertion.
  • History of any serious neurological, psychiatric, or substance use disorders that would impact study participation.
  • Women who are currently pregnant or planning to become pregnant during the study.
  • Any other medical conditions that could affect their ability to participate in exercise for the study duration (as determined by study investigators).
  • Active participation or past participation ≤3 months in any other interventional research study.
  • Unwilling to participate in all study related activities.

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Light intensity Exercise

Aerobic intensity levels: Heart rate reserve (HRR) 30-39%, 9-11 Borg Rate of Perceived Exertion (RPE) Strength intensity levels: %One Repetition Max (1RM) 40-50%, OMNI RPE 1-4

experimental: Moderate intensity Exercise

Aerobic intensity levels: HRR 40-59%, 12-13 Borg RPE Strength intensity levels: %1RM 60-80%, OMNI RPE 5-6

Interventions

Light Intensity Exercise

12 weeks light intensity strength and endurance NeuroWell exercise program, specifically developed for individuals with neurological disorders or injuries. Participants have the intensity goals descripted in the experimental arm.

Moderate Intensity Exercise

12 weeks moderate intensity strength and endurance NeuroWell exercise program, specifically developed for individuals with neurological disorders or injuries. Participants have the intensity goals descripted in the experimental arm.

Primary outcome measure

  • Feasibility of light and moderate intensity exercise [ Time Frame: 12 weeks ]
  • Acceptability of light and moderate intensity exercise [ Time Frame: 12 weeks ]
  • Tolerability of light and moderate intensity exercise [ Time Frame: 12 weeks ]

Central Contacts and Locations

Central contacts

Clinical Trials Coordinator

651-495-6363ClinicalTrials@HealthPartners.com

Locations

HealthPartners Neuroscience Center

Recruiting

Saint Paul, Minnesota, United States, 55130

Contacts

Clinical Trial Coordinator

651-495-6363ClincialTrials@HealthPartners.com

More Information

Sponsor

HealthPartners Institute

Last update posted

Mar 23, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by HealthPartners Institute on 2026-03-23.