Recruiting

Oxygen Saturation Target

Sponsor:

University of Colorado, Denver

Code:

NCT06501118

Conditions

Respiratory Failure

Acute Hypoxemic Respiratory Failure

Acute Hypoxic Respiratory Failure

Hypoxemia

Hypoxia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Education

Epic notification alert

Study Details

Brief summary:

A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen saturation target range.

Conditions

Respiratory Failure

Acute Hypoxemic Respiratory Failure

Acute Hypoxic Respiratory Failure

Hypoxemia

Hypoxia

Study ID

NCT06501118

Start date

Sep 1, 2024

Status verified date

Aug, 2026

Completion date

Oct 15, 2026

Anticipated

Primary completion date

Sep 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Admission to ICU and requiring invasive mechanical ventilation

Exclusion Criteria:

  • Transferred patients from outside the UCHealth system\*:
  • Patients with pre-existing disease that requires chronic use of positive pressure ventilation delivered through a tracheostomy\*:
  • Pregnant women:
  • Prisoners
  • Patients receiving mechanical ventilation for less than twelve hours

Study Design

Enrollment

3600 participants

Anticipated

Allocation

Randomized

Intervention Model

Single group

Primary purpose

Other

Interventions and Outcome Measures

Arms

other: Educational intervention

SP02 target ranges will be 90-96%. Education about the specific oxygen targets will be provided to the clinical teams. Real time feedback on adherence to the Sp02 target range will be provided by virtual respiratory therapists.

other: Educational intervention Epic alert

An education-based intervention that also focuses on mitigating Occult Hypoxemia in mechanically ventilated patients, and thus utilizes the same patient population. The second intervention will notify the clinical team to an abnormal laboratory result in real time. This laboratory result is already located in the patient's Epic chart under arterial blood gas (ABG), arterial oxygen saturation (Sa02) Patient level randomization will occur in Epic as

1. alert (notification) the providers of sustained occult hypoxemia or
2. silent alert The investigators are observing physician behavior in response to alerting them that a patient has occult hypoxemia via an Epic alert.

Interventions

Education

1\) Standardized materials to discuss the rationale and procedural aspects of the intervention, including details on the specific oxygen target-related modifications to the mechanical ventilation order-set prior to starting the intervention phase.

Epic notification alert

An education-based intervention that focuses on mitigating Occult Hypoxemia in mechanically ventilated patients and thus utilizes the same patient population. The second intervention will notify the clinical team to an abnormal laboratory result in real time. This laboratory result is already located in the patient's Epic chart under arterial blood gas (ABG), arterial oxygen saturation (Sa02) Patient level randomization will occur in Epic to as

1. alert (notification) the providers of sustained occult hypoxemia
2. silent alert

Primary outcome measure

  • Ventilator Free Days (Phase I,II) [ Time Frame: 30 Days ]

Central Contacts and Locations

Central contacts

Carrie Higgins, BSN

720-560-3037carrie.higgins@cuanschutz.edu

Locations

University of Colorado

Recruiting

Aurora, Colorado, United States, 80045

More Information

Sponsor

University of Colorado, Denver

Last update posted

Aug 24, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Colorado, Denver on 2026-08-24.