Recruiting

Ujjayi

Sponsor:

Spaulding Rehabilitation Hospital

Code:

NCT06514950

Conditions

Spinal Cord Injuries

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Interventions

Ujjayi Yogic Breathing

Study Details

Brief summary:

The goal of this interventional study is to understand how regular yogic breathing practice, particularly a slow resistive yogic breathing technique called Ujjayi, would benefit individuals between the ages of 18 and 60 with spinal cord injuries. Previously yogic breathing has shown to improve respiratory function and sleep- we'd like to explore this further.

The main questions this study aims to answer are:

  • How does Ujjayi breathing affect breathing patterns in individuals with spinal cord injuries?
  • How does Ujjayi breathing affect lung function in individuals with spinal cord injuries?
  • How does Ujjayi breathing affect the part of the nervous system responsible for ventilatory control in individuals with spinal cord injuries?
  • How does Ujjayi breathing affect ventilatory perfusion (how well air and blood flow match in the lungs for efficient gas exchange) in individuals with spinal cord injuries?
  • How does Ujjayi breathing affect sleep quality in individuals with spinal cord injuries?

Participants will undergo six weeks of training in Ujjayi breathing. Before and after this period, they will visit the lab for measurements of blood pressure, pulse, blood oxygen levels, and breathing. They will also perform several tests:

  • Pulmonary function testing to assess lung capacity and respiratory muscle strength.
  • Pace breathing frequency to four pre-recorded audio files at various breathing rates.
  • Breathing exercises involving higher levels of carbon dioxide for a short time.
  • Breathing exercises involving lower levels of oxygen for a short time.
  • At-home sleep evaluation.

Between the two laboratory testing sessions, participants will practice yogic resistance breathing (Ujjayi breathing) for six weeks.

Conditions

Spinal Cord Injuries

Study ID

NCT06514950

Start date

Aug 1, 2024

Status verified date

Mar, 2026

Completion date

Apr 1, 2027

Anticipated

Primary completion date

Jan 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Spinal cord injury
  • American Spinal Injury Association Impairment Scale (AIS) score of A, B, or C
  • Aged 18-60 years
  • Wheelchair user
  • Medically stable and able to follow directions
  • Body mass index of 18.5 - 35 kg/m2

Exclusion Criteria:

  • Resting blood pressure of >140/90 mmHg
  • Current use of tobacco or cardioactive medications (except medication to support blood pressure)
  • Significant arrhythmia
  • Bleeding disorder
  • Pulmonary disease
  • Coronary artery disease
  • Diabetes
  • Renal disease
  • Cancer
  • Epilepsy or other neurological diseases
  • Current use of CPAP/BIPAP
  • Has smartphone or device incompatible with the PranaTM application

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Ujjayi yogic breathing training

This study will be a small (N = 20) prospective cohort study with a single unblinded intervention of Ujjayi resistance breathing.

Interventions

Ujjayi Yogic Breathing

Participants will undergo 6 weeks of resistive yogic breathing (Ujjayi) upon exhalation (first three weeks) and upon inhalation and exhalation (second three weeks).

Primary outcome measure

  • Ventilatory pattern after regular Ujjayi breathing [ Time Frame: Change in ventilatory pattern, Time Frame: Baseline, Week 6 ]
  • Pulmonary function after regular Ujjayi breathing [ Time Frame: Change in pulmonary function, Time Frame: Baseline, Week 6 ]
  • Central and peripheral chemosensitivity after regular Ujjayi breathing [ Time Frame: Change in central and peripheral chemosensitivity, Time Frame: Baseline, Week 6 ]
  • Ventilatory perfusion after regular Ujjayi breathing [ Time Frame: Change in ventilatory perfusion, Time Frame: Baseline, Week 6 ]
  • Sleep quality after regular Ujjayi breathing [ Time Frame: Change in sleep quality, Time Frame: Baseline, Week 6 ]

Central Contacts and Locations

Central contacts

Locations

Spaulding Rehabilitation Hospital

Recruiting

Cambridge, Massachusetts, United States, 02138

Contacts

More Information

Sponsor

Spaulding Rehabilitation Hospital

Last update posted

Mar 5, 2026

Last verified

Mar, 2026

Keywords

  • SCI, Ujjayi, yogic breathing, pranayama

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Spaulding Rehabilitation Hospital on 2026-03-05.