Recruiting
Early Phase 1

Observational Study

Sponsor:

University of Missouri-Columbia

Code:

NCT06520982

Conditions

Women

Sympathetic Nervous System

Aging

Blood Flow

Eligibility Criteria

Sex: Female

Age: 18 - 70

Healthy Volunteers: Accepted

Interventions

Norepinephrine

Isoproterenol

Acetylcholine

Nitroprusside

Estrogen

Study Details

Brief summary:

Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

Conditions

Women

Sympathetic Nervous System

Aging

Blood Flow

Study ID

NCT06520982

Start date

Sep 20, 2024

Status verified date

Nov, 2025

Completion date

Jun 30, 2028

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 70

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Assigned female at birth (AFAB)
  • 18-70 years of age

Exclusion Criteria:

  • Assigned male at birth (AMAB)
  • Pregnancy, breastfeeding
  • Body mass index ≥30 kg/m2
  • Taking medications known to affect metabolic, autonomic, and/or respiratory function
  • Oral hormonal contraception in last 6 month
  • History of hormone replacement therapy
  • History of hyster- or oophor-ectomy
  • Current smoking/Nicotine use
  • Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
  • Chronic disease
  • Blood pressure ≥140/90 mmHg
  • Communication barriers

Study Design

Enrollment

64 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: Women

Women will be 18-70 years of age

Interventions

Norepinephrine

Infused intra-arterially in a dose-response fashion

Isoproterenol

Infused intra-arterially in a dose-response fashion

Acetylcholine

Infused intra-arterially in a dose-response fashion

Nitroprusside

Infused intra-arterially in a dose-response fashion

Estrogen

Infused intra-arterially

Primary outcome measure

  • Magnitude of forearm blood flow [ Time Frame: Change from baseline during infusion ]

Central Contacts and Locations

Central contacts

Jacqueline K Limberg

573-882-2420limbergj@missouri.edu

Locations

University of Missouri-Columbia

Recruiting

Columbia, Missouri, United States, 65211

Contacts

Jacqueline K Limberg, Ph.D.

573-882-2420limbergj@missouri.edu

More Information

Sponsor

University of Missouri-Columbia

Last update posted

Nov 26, 2025

Last verified

Nov, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Missouri-Columbia on 2025-11-26.