Recruiting

MBL vs. CLL

Sponsor:

Mayo Clinic

Code:

NCT06536452

Conditions

Chronic Lymphocytic Leukemia

Monoclonal B-Cell Lymphocytosis

Eligibility Criteria

Sex: All

Age: 40+

Healthy Volunteers: Accepted

Interventions

Non-Interventional Study

Study Details

Brief summary:

This study evaluates hematopoiesis to determine how MBL/CLL affected bone marrow responds to fight off infections in the body.

Conditions

Chronic Lymphocytic Leukemia

Monoclonal B-Cell Lymphocytosis

Study ID

NCT06536452

Start date

Nov 18, 2016

Status verified date

Mar, 2026

Completion date

Nov 18, 2028

Anticipated

Primary completion date

Nov 18, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Subjects in the CLL cohort who are eligible for these studies will have a clinically established diagnosis of CLL as assessed by flow cytometry and will include subjects who

  • Remain untreated
  • Are currently being treated
  • Who have already been treated
  • Subjects in the MBL cohort will have a clinically established diagnosis of MBL
  • Healthy age-matched control subjects
  • Healthy younger control subjects aged > 40 years

Exclusion Criteria:

  • Anyone under 40
  • Healthy control subjects must not have a diagnosis of CLL or MBL

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Arms

Observational

Patients undergo blood sample collection and bone marrow aspiration and biopsy and have their medical records reviewed on study.

Interventions

Non-Interventional Study

Non-interventional study

Primary outcome measure

  • Effects of MBL on bone marrow function [ Time Frame: Baseline ]
  • Effects of CLL on bone marrow function [ Time Frame: Baseline ]

Central Contacts and Locations

Locations

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Clinical Trials Referral Office

855-776-0015mayocliniccancerstudies@mayo.edu

Principal Investigator:

Neil E. Kay, M.D.

More Information

Sponsor

Mayo Clinic

Last update posted

Mar 31, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-03-31.