Recruiting

Hypofractionated Radiotherapy

Sponsor:

Jonsson Comprehensive Cancer Center

Code:

NCT06538337

Conditions

Endometrial Cancer

Cervical Cancer

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

External beam Radiotherapy

Study Details

Brief summary:

After surgery to remove the main endometrial and/or cervical tumor, most women receive radiation therapy. This study uses hypo-fractionated radiation therapy, which is a type of radiation therapy in which the total prescribed dose of radiation is delivered in fewer but larger doses than conventional or standard radiotherapy.

This research study aims to determine if hypo-fractionated radiation therapy given after surgery can improve treatment tolerability (i.e., fewer treatments) with comparable side effects.

Participants will be in the study for about 5 years:

Radiation therapy:

  • 5 daily treatment sessions of MRI or CT-Guided Stereotactic Body Radiation Therapy (SBRT).
  • Each treatment session will occur on a weekday (typically consecutive weekdays) and will last approximately an hour.

Treatment Follow-Up:

  • Check-up Appointment and answer questions at 3 months post RT
  • Check-up Appointments with physical exam every 6 months (+/- 4 weeks) for up to 5 years.

Conditions

Endometrial Cancer

Cervical Cancer

Study ID

NCT06538337

Start date

Jul 24, 2024

Status verified date

Aug, 2026

Completion date

Jul 26, 2032

Anticipated

Primary completion date

Jul 26, 2031

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Histologically confirmed endometrial or cervical cancer
  • Surgical resection of the primary tumor
  • International Federation of Gynecology and Obstetrics (FIGO) Stage IA-IVB endometrial cancer OR FIGO Stage IA-IIA cervical cancer that meets indications for receiving adjuvant pelvic radiotherapy alone as standard of care
  • Age ≥ 18 years old
  • Karnofsky performance status (KPS) ≥ 60 or Eastern Cooperative Oncology Group (ECOG) 0-2

Exclusion Criteria:

  • Must not meet indications for receiving concurrent chemotherapy as standard of care
  • Active treatment of a separate malignancy
  • History of prior irradiation to the area to be treated

Study Design

Enrollment

60 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Hypofractionated External beam Radiotherapy

5 daily treatment sessions of MRI or CT-Guided Stereotactic Body Radiation Therapy (SBRT).

Interventions

External beam Radiotherapy

Five fractions of radiation therapy using adaptive planning and CT or MRI guidance (6 Gy per fraction) delivered once every other day excluding weekends and holidays

Primary outcome measure

  • Evaluate acute radiation toxicity [ Time Frame: treatment to 12 weeks after completion of radiotherapy ]

Central Contacts and Locations

Central contacts

Christy Palodichuk

310-794-2971cpalodichuk@mednet.ucla.edu

Vincent Basehart

310-267-8954vbasehart@mednet.ucla.edu

Locations

University of California at Los Angeles

Recruiting

Los Angeles, California, United States, 90095

Contacts

Christy Palodichuk

310-794-2971cpalodichuk@mednet.ucla.edu

Vincent Basehart

310-267-8954vbasehart@mednet.ucla.edu

Principal Investigator:

Puja S. Venkat, MD

More Information

Sponsor

Jonsson Comprehensive Cancer Center

Last update posted

Aug 20, 2026

Last verified

Aug, 2026

Keywords

  • endometrial
  • cervical
  • SBRT

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Jonsson Comprehensive Cancer Center on 2026-08-20.