Recruiting

Median vs. Ulnar

Sponsor:

Loma Linda University

Code:

NCT06553131

Conditions

Neuromuscular Blockade

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Neuromuscular Transmission Monitoring

Study Details

Brief summary:

Medications used to relax the muscles are used during surgery. The amount of muscle relaxation can monitored with devices that stimulate a specific nerve and evaluate the muscle response. The response to, and recovery from, medications that relax the muscles are best described for a nerve in the arm called the ulnar nerve. The investigators believe that other nerves in the arm, such as the median nerve, could be used to monitor the amount of muscle relaxation. The purpose of this study is to compare the muscle response at two different nerve sites after giving medications to relax the muscles.

This study is going to measure the depth of muscle relaxation during surgery at two different sites. The muscle response to stimulation of the ulnar nerve (located in the arm) will be compared to the muscle response to stimulation of the median nerve (also located in the arm).

Conditions

Neuromuscular Blockade

Study ID

NCT06553131

Start date

Dec 26, 2024

Status verified date

Jan, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults 18 - 75 years of age who are able to provide consent
  • Scheduled for elective surgery requiring muscle relaxation, in a supine position under general anesthesia, with an anticipated duration of at least 1.5 hours

Exclusion Criteria:

  • Contraindication to rocuronium use
  • Comorbidities that may prolong the duration of neuromuscular blockade or alter pharmacodynamics and/or pharmacokinetics, such as:
  • Neuromuscular disease
  • Expected or known difficult airway
  • Rocuronium allergy
  • BMI < 18.5 or > 40
  • History of adhesive allergy
  • Upper extremity weakness, limb deformity, or absence of all or part of an upper limb
  • Patients undergoing surgical procedures requiring cardiopulmonary bypass

Study Design

Enrollment

32 participants

Anticipated

Interventions and Outcome Measures

Arms

Surgical Patients Receiving Non-Depolarizing Neuromuscular Blockade

Surgical patients having surgery that requires muscle relaxation with non-depolarizing neuromuscular blockers and monitoring of the depth of muscle blockade.The muscle response to nerve stimulation will be compared between the ulnar and median nerve.

Interventions

Neuromuscular Transmission Monitoring

A neuromuscular transmission module connected to electrodes applied to the skin and positioned to provide stimulation of a single nerve and monitor the muscular response to nerve stimulation

Primary outcome measure

  • Neuromuscular transmission nerve monitoring concordance [ Time Frame: Change in time between administration of rocuronium at beginning of surgery and the appearance of one post-tetanic twitch on a monitor, typically 20 minutes after sedation ]

Central Contacts and Locations

Central contacts

Melissa D McCabe, MD, MSCR

909 558 4475mmccabe@llu.edu

Michael Benggon, MD

909 558 4475mbenggon@llu.edu

Locations

Loma Linda University Troesch Medical Center

Recruiting

Loma Linda, California, United States, 92354

Contacts

Melissa M McCabe, MD

909-558-4475mmccabe@llu.edu

Morgan E Blazy, BS

9095584227MBlazy@llu.edu

Principal Investigator:

Melissa D McCabe, MD

More Information

Sponsor

Loma Linda University

Last update posted

Jan 30, 2026

Last verified

Jan, 2026

Keywords

  • Median Nerve
  • Neuromuscular Blockade
  • Ulnar Nerve

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Loma Linda University on 2026-01-30.