Recruiting

Financial Incentives

Sponsor:

Mayo Clinic

Code:

NCT06556433

Conditions

Smoking Cessation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Financial Incentive Rewards

Study Details

Brief summary:

The current study will conduct an RCT to evaluate the effectiveness of a family-based incentive intervention with Alaska Native/American Indian families. The experimental arm will be compared to a control arm on biochemically-confirmed smoking abstinence at 6- and 12-months post-intervention.

Conditions

Smoking Cessation

Study ID

NCT06556433

Start date

Sep 3, 2024

Status verified date

Aug, 2026

Completion date

Apr 30, 2028

Anticipated

Primary completion date

Jan 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Index Participant Inclusion Criteria:

  • Alaska Native/American Indian (ANAI) person (based on self-reported race) and reside in Alaska.
  • Age ≥18 years.
  • Self-report smoking in the past 7 days, biochemically verified with saliva cotinine ≥ 30 ng/mL (positive result based on at-home saliva swab test provided by study team).
  • Smoked ≥ 3 cigarettes per day over the past 3 months.
  • Considering or willing to make a quit attempt.
  • Have or will nominate one adult family member to enroll with them.
  • Own or have access to a mobile phone or tablet with Internet and text messaging capabilities, or will be loaned an iPad for the study duration
  • Willing to upload photos of self during completion of smoking status tests.
  • Willing to complete and sign an Internal Revenue Service (IRS) W-9 tax identification form if they wish to receive payments on the study.
  • Willing to provide written informed consent and participate in study-related tests and procedures.

Index Participant Exclusion Criteria:

  • Already enrolled in the study with another family member.
  • Participated in a prior study phase.

Family Member Participant Inclusion Criteria (regardless of smoking status or residence with the index participant):

  • Age ≥18 years.
  • Defined as family and nominated by the index participant, or have an ANAI family member who is ≥18 years and smokes that they would like to support in quitting.
  • Own or have access to a mobile phone or tablet with Internet and text messaging capabilities, or will be loaned an iPad for the study duration.
  • Willing to complete and sign an IRS W-9 tax identification form if they wish to receive payments on the study.
  • Willing to provide written informed consent and participate in study related tests and procedures.

Both men and women, those from non-ANAI racial/ethnic groups, and those who live outside of Alaska in the United States will be eligible family member participants.

Family Member Participant Exclusion Criteria:

  • Already enrolled with another family member.
  • Participated in a prior study phase.

After the randomized controlled trial, qualitative interviews will be conducted with index participants, family member participants, and Alaska Tribal Health System Stakeholders to inform program implementation. Healthcare providers, cessation specialists, Elder advisors, and Tribal Health System leaders and stakeholders will be invited by the Alaska Native Tribal Health Consortium team and separately consented and interviewed.

Study Design

Enrollment

1312 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Rewards Group

Index participants in the Rewards Group will be scheduled to complete smoking status check-ins six times during the 6-month Treatment Phase: weekly for four weeks, then at three and six months. At each check-in, cigarette smoking abstinence will be assessed. Participants in the Rewards Group will receive informational materials on smoking cessation.

no intervention: Comparison Group

Index participants in the Comparison Group will be scheduled to complete smoking status check-ins six times during the 6-month Treatment Phase: weekly for four weeks, then at three and six months. At each check-in, cigarette smoking abstinence will be assessed. Participants in the Comparison Group will receive informational materials on smoking cessation.

Interventions

Financial Incentive Rewards

Participants in the Rewards Group will have abstinence reinforced through escalating financial incentives.

Primary outcome measure

  • Change in smoking status [ Time Frame: 6 months, 12 months ]

Central Contacts and Locations

Central contacts

Locations

Alaska Native Tribal Health Consortium

Recruiting

Anchorage, Alaska, United States, 99508

Contacts

More Information

Sponsor

Mayo Clinic

Last update posted

Aug 10, 2026

Last verified

Aug, 2026

Keywords

  • Alaska Native
  • Family
  • Financial Incentive
  • Smoking Cessation
  • Contingency Management

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-08-10.