Recruiting

ECV with Defibrillator

Sponsor:

Ottawa Heart Institute Research Corporation

Code:

NCT06556667

Conditions

Cardioversion

Atrial Fibrillation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

biphasic defibrillator with maximum energy of 200J (® Zoll)

biphasic defibrillator with maximum energy of 360J (® Physio-Control)

Study Details

Brief summary:

Can Electrical Cardioversion (ECV) for AF be improved. It is the preferred method to restore sinus rhythm in patients with AF in whom a rhythm-control strategy is pursued.

Hypothesis:

ECV success rates will be greater with a biphasic defibrillator with maximum energy of 360J (® Physio-Control) compared to a biphasic defibrillator with maximum energy of 200J (® Zoll)

Conditions

Cardioversion

Atrial Fibrillation

Study ID

NCT06556667

Start date

Mar 31, 2025

Status verified date

Jan, 2026

Completion date

Sep 1, 2027

Anticipated

Primary completion date

Sep 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients age > 18 years.
  • Persistent atrial fibrillation.
  • Scheduled for elective cardioversion at UOHI
  • Patient is within the circle of care of UOHI Electrophysiology staff

Exclusion Criteria:

  • Known left-atrial appendage thrombus.
  • Contraindication to appropriate anticoagulation.
  • Patient is included in another randomized clinical trial.
  • Patient does not meet all of the above listed inclusion criteria.

Study Design

Enrollment

376 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: 200J

biphasic defibrillator with maximum energy of 200J (® Zoll)

active comparator: 360J

biphasic defibrillator with maximum energy of 360J (® Physio-Control)

Interventions

biphasic defibrillator with maximum energy of 200J (® Zoll)

Cardioversion

biphasic defibrillator with maximum energy of 360J (® Physio-Control)

Cardioversion

Primary outcome measure

  • ECV success [ Time Frame: 2 seconds ]

Central Contacts and Locations

Central contacts

Tammy Knight

613-696-7000tknight@ottawaheart.ca

David Birnie

613-696-7000dbirnie@ottawaheart.ca

Locations

University of Ottawa Heart Institute

Recruiting

Ottawa, Ontario, Canada, K1Y 4W7

Contacts

Dr. Mehrdad Golian

mgolian@ottawaheart.ca

Tammy Knight

tknight@ottawaheart.ca

Principal Investigator:

Dr. Mehrdad Golian

More Information

Sponsor

Ottawa Heart Institute Research Corporation

Last update posted

Feb 3, 2026

Last verified

Jan, 2026

Keywords

  • defibrillator

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Ottawa Heart Institute Research Corporation on 2026-02-03.