Recruiting

TMS

Sponsor:

Medical University of South Carolina

Code:

NCT06562153

Conditions

Depression

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

Neuroimaging with Magnetic Resonance Imaging (MRI)

Study Details

Brief summary:

This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in Major Depressive Disorder (MDD) patients can track brain recovery of MDD patients over an accelerated antidepressant transcranial magnetic stimulation (TMS) treatment.

Conditions

Depression

Study ID

NCT06562153

Start date

Sep 23, 2024

Status verified date

Oct, 2025

Completion date

Aug 5, 2026

Anticipated

Primary completion date

Aug 5, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18-65
  • Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
  • DSM-IV diagnosis of MDD

Exclusion Criteria:

  • Unable to speak English.
  • Contraindicated for MRI.
  • Any current or recent untreated medical, neurological, or psychiatric conditions
  • Metal implant devices in the head, heart, or neck.
  • History of brain surgery.
  • History of cortisol medication use or electroconvulsive therapy.
  • Comorbidity with other psychiatric/neurological illnesses or personality disorders
  • History of myocardial infarction or arrhythmia, bradycardia.
  • Personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury.
  • Individuals suffering from frequent/severe headaches.
  • Moderate to severe alcohol or substance use disorder.
  • Pregnancy

Study Design

Enrollment

20 participants

Anticipated

Interventions and Outcome Measures

Arms

Volunteer Participants with Major Depressive Disorders (MDD)

20 patients with MDD receiving 5-day accelerated transcranial magnetic stimulation therapy (TMS) from the clinic will be recruited to participate in this observational neuroimaging study. Participants will undergo two fMRI scans at baseline and post-treatment.

Interventions

Neuroimaging with Magnetic Resonance Imaging (MRI)

MRI will be used to observe brain states over time.

Primary outcome measure

  • Dynamic brain state change after 5-day transcranial magnetic stimulation (TMS) treatment compared to baseline [ Time Frame: 5 days ]

Central Contacts and Locations

Central contacts

Marion Wood

843-792-9502woodma@musc.edu

Locations

30 Bee Street

Recruiting

Charleston, South Carolina, United States, 29429

Contacts

Marion Wood

8437928502woodma@musc.edu

Principal Investigator:

Xiaolong Peng, Ph.D.

More Information

Sponsor

Medical University of South Carolina

Last update posted

Oct 16, 2025

Last verified

Oct, 2025

Keywords

  • Brain
  • Depression

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Medical University of South Carolina on 2025-10-16.