Recruiting

Care.coach Avatar™

Sponsor:

Victor Wang

Code:

NCT06564233

Conditions

Hematopoietic Stem Cell Transplantation

Cancer

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Not accepted

Interventions

care.coach Avatar™

Study Details

Brief summary:

The overall goal of this study is to assess the efficacy of the care.coach Avatar™ in improving anxiety and quality of life for patients undergoing outpatient transplant. After care.coach Avatar™ content and scheduling ("digital intervention" or "program") has been optimized for outpatient allogeneic hematopoietic stem cell transplantation (HCT), a randomized controlled trial (RCT) will be conducted of the digital versus usual supportive care program for outpatient HCT recipients. Potential improvements in anxiety and quality of life will be evaluated, with the intent of increasing comfortability with outpatient transplant and expanding the population of eligible patients willing to receive their transplants in an outpatient setting.

Conditions

Hematopoietic Stem Cell Transplantation

Cancer

Study ID

NCT06564233

Start date

Oct 21, 2024

Status verified date

Mar, 2026

Completion date

Nov 29, 2026

Anticipated

Primary completion date

Sep 20, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18+
  • Seen for outpatient RIC HCT (prior to D0, generally D-6).

Exclusion Criteria:

  • Deemed by clinical staff or research assistant (RA) to be unable to converse with an avatar, due to: severe, uncorrectable hearing or vision impairment; severe speech impairment that precludes understanding by staff (or by the avatar).
  • Not fluent in English.

Study Design

Enrollment

90 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: care.coach Avatar™

care.coach Avatar™ with usual supportive care. The avatar program includes companionship, HCT educational modules, relaxation and mindfulness exercises, simple (seated) physical exercises, nightly check ins, and symptom self-management as needed.

no intervention: Usual Supportive Care

Traditional supportive care comprising of a binder with HCT educational materials and regular meetings with a transplant nurse.

Interventions

care.coach Avatar™

care.coach Avatar™ ("avatar") is a conversational relational agent that serves as a virtual companion and appears on a tablet device as an animated pet avatar. Each avatar is supervised by a 24x7 remote team of trained human staff whose abilities are augmented by artificial intelligence (AI) and software-driven health coaching and clinical protocols for consistency, automation, and scale. This unique human-in-the-loop design enables safe, empathic, natural conversations that form the basis for trusting relations and lasting behavior change. In addition to being a companion, the avatar educates patients about their condition, helps manage symptoms, and reinforces other healthy habits. Independent studies have demonstrated improved outcomes at a reduced cost of care. A pilot study demonstrated the feasibility of care.coach Avatar™ as a psychosocial support and health coach in hospitalized HCT patients. More research is needed to assess efficacy and applications in other HCT settings.

Primary outcome measure

  • HADS-A [ Time Frame: Baseline, Day 20 (D+20) post-transplant ]

Central Contacts and Locations

Central contacts

Locations

Dana-Farber Cancer Institute

Recruiting

Boston, Massachusetts, United States, 02215

Contacts

Principal Investigator:

Gregory A Abel, MD

More Information

Sponsor

Victor Wang

Last update posted

Mar 6, 2026

Last verified

Mar, 2026

Keywords

  • health coaching
  • conversational relational agents

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Victor Wang on 2026-03-06.