Recruiting

Resveratrol

Sponsor:

Texas Tech University

Code:

NCT06585865

Conditions

Sarcopenia

Anabolic Resistance

Eligibility Criteria

Sex: All

Age: 60+

Healthy Volunteers: Accepted

Interventions

Resistance training

Resveratrol 500 mg oral once daily.

Placebo

Study Details

Brief summary:

The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether circulating vehicles of inter-organ communication (extracellular vesicles) and their cargo might help explain those responses. The investigators will also examine whether resveratrol supplementation improves blood vessel function and cognitive function (brain health) in response to strength training.

Conditions

Sarcopenia

Anabolic Resistance

Study ID

NCT06585865

Start date

Jun 13, 2025

Status verified date

Jul, 2026

Completion date

Aug, 2027

Anticipated

Primary completion date

Jul, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 60+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 60+
  • Minimally active (less than 1 hour of structured exercise/week other than walking)
  • No resistance training for the previous 6 months
  • Not currently taking resveratrol supplements
  • Stable medication, supplement, dietary, and physical activity regimens for the previous 3 months and no plans to change throughout the study period
  • Body mass at least 110 lbs

Exclusion Criteria:

  • Medical complications that could increase risk during exercise (e.g., cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes, orthopedic contraindication to exercise, kidney disease, etc.)
  • Cannabis or nicotine use
  • Consume more than 7 alcohol-containing beverages per week

Study Design

Enrollment

36 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Resveratrol (RSV) group

Participants will be randomized to consume resveratrol (500 mg) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.

placebo comparator: Placebo

Participants will be randomized to consume placebo capsules (cellulose, visually identical to resveratrol capsules) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.

Interventions

Resistance training

After pre-testing, participants will perform full-body strength training three times per week for two 6-week blocks. The acute program variables (sets, repetitions, training frequency) will follow a non-linear periodized, progressive design consisting of muti-joint and single-joint exercises. Exercise stress will be varied by using different exercises and loads. The two training blocks will be separated by a mid-intervention testing week, allowing for the study team to monitor participants' progress, communicate progress to participants to promote adherence, and adjust target loads as appropriate for the second half of the intervention. An additional testing week will follow the second 6-week block.

Resveratrol 500 mg oral once daily.

Participants will be randomized to consume resveratrol (500 mg) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.

Placebo

Participants will be randomized to consume placebo capsules (cellulose, visually identical to resveratrol capsules) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.

Primary outcome measure

  • Circulating extracellular vesicle microRNA profile [ Time Frame: During pre-, mid-, and post-testing (each separated by about 6 weeks) ]
  • Muscle torque [ Time Frame: During pre-, mid-, and post-testing (each separated by about 6 weeks) ]
  • Muscle fatigability [ Time Frame: During pre-, mid-, and post-testing (each separated by about 6 weeks) ]
  • Muscle strength [ Time Frame: During pre-, mid-, and post-testing (each separated by about 6 weeks) ]
  • Appendicular skeletal muscle mass index [ Time Frame: During pre-, mid-, and post-testing (each separated by about 6 weeks) ]

Central Contacts and Locations

Central contacts

Danielle E Levitt, PhD

806-834-1830danielle.levitt@ttu.edu

Jacob A Mota, PhD

806-834-8772jacob.mota@ttu.edu

Locations

Department of Kinesiology & Sport Management, Texas Tech University

Recruiting

Lubbock, Texas, United States, 79409

Contacts

Danielle E Levitt, PhD

806-834-1830danielle.levitt@ttu.edu

More Information

Sponsor

Texas Tech University

Last update posted

Jul 7, 2026

Last verified

Jul, 2026

Keywords

  • Resistance training
  • Aging
  • Resveratrol
  • Sarcopenia
  • Extracellular Vesicles
  • MicroRNAs

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Texas Tech University on 2026-07-07.