Recruiting
Phase 3

Efgartigimod IV

Sponsor:

University Health Network, Toronto

Code:

NCT06587867

Conditions

Efgartigimod

Generalized Myasthenia Gravis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

efgartigimod

Study Details

Brief summary:

This is to study the efficacy, safety and tolerability of efgartigimod in patients with seronegative generalized myasthenia gravis. This is an open label study. There will be 30 participants to enroll at University Health Network Toronto General Hospital. Study duration is 43 weeks from screening to end of study.

Conditions

Efgartigimod

Generalized Myasthenia Gravis

Study ID

NCT06587867

Start date

Jun 1, 2023

Status verified date

Aug, 2024

Completion date

May, 2025

Anticipated

Primary completion date

May, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Evidence of signed and dated informed consent document(s) indicating that the subject has been informed of all pertinent aspects of the trial. Subjects must be willing and able to comply with the protocol, complete study assessments, and return for follow-up visits.
  • Male or female subjects ≥ 18 years old.
  • Diagnosis of SN MG defined as: (a) clinical syndrome consistent with a diagnosis of MG, and not otherwise explained by another condition, (b) abnormal neuromuscular transmission test results demonstrated by single-fiber electromyography or repetitive nerve stimulation; and (c) negative serologic test for anti-AChR and anti- MuSK antibodies as confirmed at screening, (d) limited, if any, response to therapy with immunotherapy and/or antiacetylcholinesterase (AChE) treatment. Further testing for low affinity antibodies to rapsyn-clustered AChR by cell-based assays will be done at baseline and the results included as part of subgroup analysis. All patients will have a negative genetic test for congenital myasthenic syndromes by history or at baseline to exclude the possibility of congenital myasthenic syndrome mimicking SN MG.
  • MGFA Clinical Classification Class II, III, or IV at the time of screening and baseline.
  • Moderate to severe myasthenia gravis as defined by a generalized myasthenia gravis impairment index score > 11 or MG-ADL score of at least 5 (with >50% of the score due to non-ocular symptoms) and a PASS response of "No" and a SSQ of < 70% with at least 6 months of historical data as the baseline.
  • Stable or worsening MG as defined by MGII remaining stable or increasing in the 4 week run-in interval.
  • Patients are required to be on a stable dose of their MG treatment (Standard of care-SoC) for at least one month prior to screening. The SoC is limited to AChE inhibitors, steroids and NSISTs (e.g., azathioprine, methotrexate, cyclosporine, tacrolimus, and mycophenolate mofetil. There is no requirement for specific generalised myasthenia gravis therapies.
  • Patients who discontinued early from previous trials of efgartigimod for reasons other than pregnancy, rescue therapy or a SAE can be included.
  • Females of childbearing potential who are sexually active with a non-sterilized male partner must be willing to use at least one highly effective contraception method from the time of screening and for 3 months after the final dose of efgartigimod.
  • Non-sterilized males who are sexually active with a female partner of childbearing potential must be willing to use a condom for the duration of the study and for 3 months after the last dose of efgartigimod. Because male condom is not a highly effective contraception method, it is strongly recommended that female partners of a male study subject also use a highly effective method of contraception throughout this period.
  • Vital signs, electrocardiogram (ECG), and laboratory parameters within the normal ranges at screening, or, if outside normal ranges, deemed not clinically significant by the Investigator.
  • Patient has documented IgG >6 g/L within one month of screening
  • Vaccinated for COVID-19 at least 2 weeks prior to screening visit.

Exclusion Criteria:

  • Patients who discontinued early from trials of efgartigimod for pregnancy or rescue reasons or an SAE that was likely to result in a life-threatening situation or pose a serious safety risk.
  • Pregnant and lactating women, and those intending to become pregnant during the trial or within 3 months after the last dosing. Women of childbearing potential should have a negative urine pregnancy test at screening and baseline.
  • Male patients who are sexually active and do not intend to use effective methods of contraception (as mentioned above) during the trial or within 3 months after the last dosing or male patients who plan to donate sperm during the trial or within 3 months after the last dosing.
  • Patients with known hepatitis B virus (HBV), hepatitis C virus (HCV) or human immunodeficiency virus (HIV) seropositivity.
  • Patients with known autoimmune disease other than MG (e.g., rheumatoid arthritis) which in the investigator opinion would interfere with an accurate assessment of clinical symptoms.
  • Patients with clinical evidence of other significant disease or patients who underwent a recent major surgery, which could confound the results of the trial or put the patient at undue risk.
  • Patients with renal/hepatic function impairment as defined by (Cr>1.5 x elevated) and/or (transaminases > 2.5 x elevation) at screening.
  • Patients with known medical history of hypersensitivity to any of the ingredients of efgartigimod.
  • Patients who have received rituximab or eculizumab in the 6 months before screening.
  • Patients who have undergone thymectomy within 3 months of screening.
  • Patients who had intravenous immunoglobulin or plasma exchange within 4 weeks of screening.
  • Patient who has clinically significant uncontrolled active or chronic bacterial, viral, or fungal infection at screening
  • Patient has received a live or a live-attenuated vaccination during the month before screening

Study Design

Enrollment

30 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

other: efgartigimod

active treatment with efgartigimod.

Interventions

efgartigimod

active drug efgartigimod to be administer

Primary outcome measure

  • Total Myasthenia Gravis Impairment Index (MGII) score [ Time Frame: through study completion for 42 weeks ]

Central Contacts and Locations

Central contacts

Eduardo Ng

4163403898eduardo.ng@uhn.ca

Locations

University Health Network, Division of Neurology, Toronto General Hospital

Recruiting

Toronto, Ontario, Canada, M5G 2C4

Contacts

Eduardo Ng

416-340-3898Eduardo.Ng@uhn.ca

More Information

Sponsor

University Health Network, Toronto

Last update posted

Sep 19, 2024

Last verified

Aug, 2024

Keywords

  • seronegative
  • generalized myasthenia gravis

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University Health Network, Toronto on 2024-09-19.